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High-throughput mRNA-seq atlas of human placenta shows vast transcriptome remodeling from first to third trimester.
Gonzalez TL, Wertheimer S, Flowers AE, Wang Y, Santiskulvong C, Clark EL, Jefferies CA, Lawrenson K, Chan JL, Joshi NV, Zhu Y, Tseng HR, Karumanchi SA, Williams J, Pisarska MD. Gonzalez TL, et al. Among authors: chan jl. bioRxiv [Preprint]. 2023 Jun 7:2023.06.06.543972. doi: 10.1101/2023.06.06.543972. bioRxiv. 2023. Update in: Biol Reprod. 2024 May 9;110(5):936-949. doi: 10.1093/biolre/ioae007 PMID: 37333287 Free PMC article. Updated. Preprint.
Evaluation of subretinally delivered Cas9 ribonucleoproteins in murine and porcine animal models highlights key considerations for therapeutic translation of genetic medicines.
Wei SC, Cantor AJ, Walleshauser J, Mepani R, Melton K, Bans A, Khekare P, Gupta S, Wang J, Soares C, Kiwan R, Lee J, McCawley S, Jani V, Leong WI, Shahi PK, Chan J, Boivin P, Otoupal P, Pattnaik BR, Gamm DM, Saha K, Gowen BG, Haak-Frendscho M, Janatpour MJ, Silverman AP. Wei SC, et al. Among authors: chan j. bioRxiv [Preprint]. 2024 Dec 30:2024.12.30.630799. doi: 10.1101/2024.12.30.630799. bioRxiv. 2024. PMID: 39803585 Free PMC article. Preprint.
Development of novel GI-centric prostaglandin E2 receptor type 4 (EP4) agonist prodrugs as treatment for ulcerative colitis and other intestinal inflammatory diseases.
Kantham S, Yu H, Cantelli CR, Chen G, Ma C, Chan JJ, Yang H, Tsai K, Lassueur K, Vallance BA, Jacobson K, Young RN. Kantham S, et al. Among authors: chan jj. Bioorg Med Chem Lett. 2025 Jan 8:130093. doi: 10.1016/j.bmcl.2025.130093. Online ahead of print. Bioorg Med Chem Lett. 2025. PMID: 39793629
Bidirectional histone monoaminylation dynamics regulate neural rhythmicity.
Zheng Q, Weekley BH, Vinson DA, Zhao S, Bastle RM, Thompson RE, Stransky S, Ramakrishnan A, Cunningham AM, Dutta S, Chan JC, Di Salvo G, Chen M, Zhang N, Wu J, Fulton SL, Kong L, Wang H, Zhang B, Vostal L, Upad A, Dierdorff L, Shen L, Molina H, Sidoli S, Muir TW, Li H, David Y, Maze I. Zheng Q, et al. Among authors: chan jc. Nature. 2025 Jan 8. doi: 10.1038/s41586-024-08371-3. Online ahead of print. Nature. 2025. PMID: 39779849
9,998 results