Aly OM - Search Results

1

Discovery and Anticancer Screening of Novel Oxindole-Based Derivative Bearing Pyridyl Group as Potent and Selective Dual FLT3/CDK2 Kinase Inhibitor.

Soudi A, Bender O, Celik I, El-Hafeez AAA, Dogan R, Atalay A, Elkaeed EB, Alsfouk AA, Abdelhafez EMN, Aly OM, Sippl W, Ali TFS. Soudi A, et al. Among authors: aly om. Pharmaceuticals (Basel). 2024 May 20;17(5):659. doi: 10.3390/ph17050659. Pharmaceuticals (Basel). 2024. PMID: 38794229 Free PMC article.

2

Combination of an Oxindole Derivative with (-)-β-Elemene Alters Cell Death Pathways in FLT3/ITD⁺ Acute Myeloid Leukemia Cells.

Alanazi J, Bender O, Dogan R, Malik JA, Atalay A, Ali TFS, Beshr EAM, Shawky AM, Aly OM, Alqahtani YNH, Anwar S. Alanazi J, et al. Among authors: aly om. Molecules. 2023 Jul 6;28(13):5253. doi: 10.3390/molecules28135253. Molecules. 2023. PMID: 37446914 Free PMC article.

3

Discovery of oxindole-based FLT3 inhibitors as a promising therapeutic lead for acute myeloid leukemia carrying the oncogenic ITD mutation.

Bender O, Shoman ME, Ali TFS, Dogan R, Celik I, Mollica A, Hamed MIA, Aly OM, Alamri A, Alanazi J, Ahemad N, Gan SH, Malik JA, Anwar S, Atalay A, Beshr EAM. Bender O, et al. Among authors: aly om. Arch Pharm (Weinheim). 2023 Feb;356(2):e2200407. doi: 10.1002/ardp.202200407. Epub 2022 Nov 20. Arch Pharm (Weinheim). 2023. PMID: 36403191

4

Synthesis, antiproliferative, anti-tubulin activity, and docking study of new 1,2,4-triazoles as potential combretastatin analogues.

Mustafa M, Abdelhamid D, Abdelhafez EMN, Ibrahim MAA, Gamal-Eldeen AM, Aly OM. Mustafa M, et al. Among authors: aly om. Eur J Med Chem. 2017 Dec 1;141:293-305. doi: 10.1016/j.ejmech.2017.09.063. Epub 2017 Sep 28. Eur J Med Chem. 2017. PMID: 29031074

5

Tubulin inhibitors: Discovery of a new scaffold targeting extra-binding residues within the colchicine site through anchoring substituents properly adapted to their pocket by a semi-flexible linker.

Maklad RM, AbdelHafez EMN, Abdelhamid D, Aly OM. Maklad RM, et al. Among authors: aly om. Bioorg Chem. 2020 Jun;99:103767. doi: 10.1016/j.bioorg.2020.103767. Epub 2020 Apr 6. Bioorg Chem. 2020. PMID: 32325332

6

Design and Synthesis of New Hydantoin Acetanilide Derivatives as Anti-NSCLC Targeting EGFR^L858R/T790M Mutations.

Hassanin MA, Mustafa M, Abourehab MAS, Hassan HA, Aly OM, Beshr EAM. Hassanin MA, et al. Among authors: aly om. Pharmaceuticals (Basel). 2022 Jul 12;15(7):857. doi: 10.3390/ph15070857. Pharmaceuticals (Basel). 2022. PMID: 35890154 Free PMC article.

7

Computational and synthetic studies towards improving rescinnamine as an inducer of MSH2-dependent apoptosis in cancer treatment.

AbdelHafez EM, Diamanduros A, Negureanu L, Luy Y, Bean JH, Zielke K, Crowe B, Vasilyeva A, Clodfelter JE, Aly OM, Abuo-Rahma GE, Scarpinato KD, Salsbury FR Jr, King SB. AbdelHafez EM, et al. Among authors: aly om. Mol Cancer Biol. 2013;1(1):44. Mol Cancer Biol. 2013. PMID: 25485184 Free PMC article.

8

1,3,4-oxadiazole-2-thione Derivatives; Novel Approach for Anticancer and Tubulin Polymerization Inhibitory Activities.

Abdel-Aziz M, Metwally KA, Gamal-Eldeen AM, Aly OM. Abdel-Aziz M, et al. Among authors: aly om. Anticancer Agents Med Chem. 2015;16(2):269-77. doi: 10.2174/1871520615666150907093855. Anticancer Agents Med Chem. 2015. PMID: 26343141

9

Editorial (Thematic Issue: Novel Approaches to the Discovery of Selective and Targeted Anticancer Agents).

Aly OM. Aly OM. Curr Top Med Chem. 2016;16(22):2431. doi: 10.2174/156802661622160630203649. Curr Top Med Chem. 2016. PMID: 27439508 No abstract available.

10

Potent combretastatin A-4 analogs containing 1,2,4-triazole: Synthesis, antiproliferative, anti-tubulin activity, and docking study.

Mustafa M, Anwar S, Elgamal F, Ahmed ER, Aly OM. Mustafa M, et al. Among authors: aly om. Eur J Med Chem. 2019 Dec 1;183:111697. doi: 10.1016/j.ejmech.2019.111697. Epub 2019 Sep 12. Eur J Med Chem. 2019. PMID: 31536891

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