Alsfouk AA - Search Results

1

Design, synthesis, and in silico studies of new quinazolinones tagged thiophene, thienopyrimidine, and thienopyridine scaffolds as antiproliferative agents with potential p38α MAPK kinase inhibitory effects.

Alsfouk AA, Othman IMM, Anwar MM, Saleh A, Nossier ES. Alsfouk AA, et al. RSC Adv. 2025 Jan 16;15(2):1407-1424. doi: 10.1039/d4ra06744d. eCollection 2025 Jan 9. RSC Adv. 2025. PMID: 39822569 Free PMC article.

2

Integrated in Silico and in Vitro Studies of Rutin's Potential against SARS-CoV-2 through the Inhibition of the RNA-dependent RNA Polymerase.

Metwaly AM, El-Fakharany EM, Alsfouk AA, Ibrahim IM, Elkaeed EB, Eissa IH. Metwaly AM, et al. Among authors: alsfouk aa. Curr Med Chem. 2025 Jan 2. doi: 10.2174/0109298673339634241210151734. Online ahead of print. Curr Med Chem. 2025. PMID: 39757685

3

Repurposing FDA-approved drugs for COVID-19: targeting the main protease through multi-phase in silico approach.

Metwaly AM, Elkaeed EB, Alsfouk AA, Ibrahim IM, Elkady H, Eissa IH. Metwaly AM, et al. Among authors: alsfouk aa. Antivir Ther. 2024 Dec;29(6):13596535241305536. doi: 10.1177/13596535241305536. Antivir Ther. 2024. PMID: 39639531 Free article.

4

Integrated study of Quercetin as a potent SARS-CoV-2 RdRp inhibitor: Binding interactions, MD simulations, and In vitro assays.

Metwaly AM, El-Fakharany EM, Alsfouk AA, Ibrahim IM, Elkaeed EB, Eissa IH. Metwaly AM, et al. Among authors: alsfouk aa. PLoS One. 2024 Dec 3;19(12):e0312866. doi: 10.1371/journal.pone.0312866. eCollection 2024. PLoS One. 2024. PMID: 39625895 Free PMC article.

5

New N-amino-5-cyano-6-pyridones as antimicrobial small molecules endowed with DNA gyrase a inhibitory activity: design, one-pot synthesis, biological assessment and in silico insights.

Kamaly OA, Younes AS, Harras MF, Sabour R, Alsfouk AA, Ibrahim MH. Kamaly OA, et al. Among authors: alsfouk aa. BMC Chem. 2024 Nov 13;18(1):226. doi: 10.1186/s13065-024-01342-9. BMC Chem. 2024. PMID: 39538322 Free PMC article.

6

Development of novel CDK9 and CYP3A4 inhibitors for cancer therapy through field and computational approaches.

Alsfouk AA, Faris A, Cacciatore I, Alnajjar R. Alsfouk AA, et al. Front Chem. 2024 Oct 21;12:1473398. doi: 10.3389/fchem.2024.1473398. eCollection 2024. Front Chem. 2024. PMID: 39498375 Free PMC article.

7

Anti-proliferative 2,3-dihydro-1,3,4-thiadiazoles targeting VEGFR-2: Design, synthesis, in vitro, and in silico studies.

Elkady H, Elgammal WE, Mahdy HA, Zara S, Carradori S, Husein DZ, Alsfouk AA, Ibrahim IM, Elkaeed EB, Metwaly AM, Eissa IH. Elkady H, et al. Among authors: alsfouk aa. Comput Biol Chem. 2024 Dec;113:108221. doi: 10.1016/j.compbiolchem.2024.108221. Epub 2024 Sep 23. Comput Biol Chem. 2024. PMID: 39332241

8

One-pot synthesis and pharmacological evaluation of new quinoline/pyrimido-diazepines as pulmonary antifibrotic agents.

Fawzy MA, Ibrahim KH, Aly AA, Mohamed AH, Naguib Abdel Hafez SM, Abdelzaher WY, Elkaeed EB, Alsfouk AA, Abdelhafez EM. Fawzy MA, et al. Among authors: alsfouk aa. Future Med Chem. 2024;16(21):2211-2230. doi: 10.1080/17568919.2024.2394018. Epub 2024 Sep 18. Future Med Chem. 2024. PMID: 39291539 Free PMC article.

9

Discovery and Anticancer Screening of Novel Oxindole-Based Derivative Bearing Pyridyl Group as Potent and Selective Dual FLT3/CDK2 Kinase Inhibitor.

Soudi A, Bender O, Celik I, El-Hafeez AAA, Dogan R, Atalay A, Elkaeed EB, Alsfouk AA, Abdelhafez EMN, Aly OM, Sippl W, Ali TFS. Soudi A, et al. Among authors: alsfouk aa. Pharmaceuticals (Basel). 2024 May 20;17(5):659. doi: 10.3390/ph17050659. Pharmaceuticals (Basel). 2024. PMID: 38794229 Free PMC article.

10

New Theobromine Apoptotic Analogue with Anticancer Potential Targeting the EGFR Protein: Computational and In Vitro Studies.

Eissa IH, Yousef RG, Elkaeed EB, Alsfouk AA, Husein DZ, Ibrahim IM, Ismail A, Elkady H, Metwaly AM. Eissa IH, et al. Among authors: alsfouk aa. ACS Omega. 2024 Mar 27;9(14):15861-15881. doi: 10.1021/acsomega.3c08148. eCollection 2024 Apr 9. ACS Omega. 2024. PMID: 38617602 Free PMC article.

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