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Page 1
A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death.
Mannion J, Gifford V, Bellenie B, Fernando W, Ramos Garcia L, Wilson R, John SW, Udainiya S, Patin EC, Tiu C, Smith A, Goicoechea M, Craxton A, Moraes de Vasconcelos N, Guppy N, Cheung KJ, Cundy NJ, Pierrat O, Brennan A, Roumeliotis TI, Benstead-Hume G, Alexander J, Muirhead G, Layzell S, Lyu W, Roulstone V, Allen M, Baldock H, Legrand A, Gabel F, Serrano-Aparicio N, Starling C, Guo H, Upton J, Gyrd-Hansen M, MacFarlane M, Seddon B, Raynaud F, Roxanis I, Harrington K, Haider S, Choudhary JS, Hoelder S, Tenev T, Meier P. Mannion J, et al. Among authors: upton j. Immunity. 2024 Jul 9;57(7):1514-1532.e15. doi: 10.1016/j.immuni.2024.04.025. Epub 2024 May 23. Immunity. 2024. PMID: 38788712 Free article.
RIPK1 is essential for Herpes Simplex Virus-triggered ZBP1-dependent necroptosis in human cells.
Amusan OT, Wang S, Yin C, Koehler HS, Li Y, Tenev T, Wilson R, Bellenie B, Zhang T, Wang J, Liu C, Seong K, Poorbaghi SL, Yates J, Shen Y, Upton JW, Meier P, Balachandran S, Guo H. Amusan OT, et al. Among authors: upton jw. bioRxiv [Preprint]. 2024 Sep 19:2024.09.17.613393. doi: 10.1101/2024.09.17.613393. bioRxiv. 2024. PMID: 39345610 Free PMC article. Preprint.
Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity.
Lei Y, VanPortfliet JJ, Chen YF, Bryant JD, Li Y, Fails D, Torres-Odio S, Ragan KB, Deng J, Mohan A, Wang B, Brahms ON, Yates SD, Spencer M, Tong CW, Bosenberg MW, West LC, Shadel GS, Shutt TE, Upton JW, Li P, West AP. Lei Y, et al. Among authors: upton jw. Cell. 2023 Jul 6;186(14):3013-3032.e22. doi: 10.1016/j.cell.2023.05.039. Epub 2023 Jun 22. Cell. 2023. PMID: 37352855 Free PMC article.
Introduction to immunology and immune disorders.
Marshall JS, Upton JEM, Vliagoftis H, Hildebrand KJ, Byrne A, Watson W. Marshall JS, et al. Among authors: upton jem. Allergy Asthma Clin Immunol. 2024 Dec 19;20(Suppl 3):69. doi: 10.1186/s13223-024-00932-5. Allergy Asthma Clin Immunol. 2024. PMID: 39702433 Free PMC article. Review.
The Origin of Pediatric Hand Molds and Proof of Concept.
Upton J, Khouri KS. Upton J, et al. Plast Reconstr Surg Glob Open. 2024 Dec 9;12(12):e6312. doi: 10.1097/GOX.0000000000006312. eCollection 2024 Dec. Plast Reconstr Surg Glob Open. 2024. PMID: 39655246 Free PMC article.
10 practical priorities to prevent and manage serious allergic reactions: GA2LEN ANACare and EFA Anaphylaxis Manifesto.
Muraro A, de Silva D, Podesta M, Anagnostou A, Cardona V, Halken S, Smith P, Tanno LK, Turner P, Worm M, Alvaro-Lozano M, Arasi S, Asarnoj A, Barni S, Beyer K, Bilaver LA, Bird A, Bonaguro R, Brough HA, Chinthrajah RS, Cook EE, Demoulin C, Deschildre A, Dribin TE, Ebisawa M, Fernandez-Rivas M, Fiocchi A, Fleischer DM, Garrow E, Gerdts J, Giovannini M, Järvinen KM, Kelly M, Knol EF, Lack G, Lazzarotto F, Le TM, Leonard S, Lieberman J, Makris M, Mandelbaum L, Marchisotto MJ, Marino GA, Mori F, Nilsson C, Nowak-Wegrzyn A, Odemyr M, Oude Elberink HNG, Palosuo K, Patel N, Pier J, Poblete S, Rachid R, Rodríguez Del Río P, Said M, Sampson HA, Sánchez Sanz A, Schnadt S, Schultz F, Toniolo A, Upton JEM, Venter C, Vickery BP, Vlieg-Boerstra B, Wang J, Roberts G, Zuberbier T; GA2LEN ANACare Centres and EFA. Muraro A, et al. Among authors: upton jem. Clin Transl Allergy. 2024 Dec;14(12):e70009. doi: 10.1002/clt2.70009. Clin Transl Allergy. 2024. PMID: 39614094 Free PMC article. Review.
Symptomatology and Management of Adult Anaphylaxis according to Trigger: A Cross-Sectional Study.
Khalaf R, Prosty C, McCusker C, Bretholz A, Kaouache M, Clarke AE, Morris J, Lim R, Chan ES, Goldman RD, O'Keefe A, Gerdts J, Chu DK, Upton J, Hochstadter E, Moisan J, Zhang X, Protudier JLP, Abrams E, Simons E, Ruiz J, Ben-Shoshan M. Khalaf R, et al. Among authors: upton j. Int Arch Allergy Immunol. 2024 Nov 15:1-11. doi: 10.1159/000542115. Online ahead of print. Int Arch Allergy Immunol. 2024. PMID: 39551043 Free article.
Human ITGAV variants are associated with immune dysregulation, brain abnormalities, and colitis.
Ghasempour S, Warner N, Guan R, Rodari MM, Ivanochko D, Whittaker Hawkins R, Marwaha A, Nowak JK, Liang Y, Mulder DJ, Stallard L, Li M, Yu DD, Pluthero FG, Batura V, Zhao M, Siddiqui I, Upton JEM, Hulst JM, Kahr WHA, Mendoza-Londono R, Charbit-Henrion F, Hoefsloot LH, Khiat A, Moreira D, Trindade E, Espinheira MDC, Pinto Pais I, Weerts MJA, Douben H, Kotlarz D, Snapper SB, Klein C, Dowling JJ, Julien JP, Joosten M, Cerf-Bensussan N, Freeman SA, Parlato M, van Ham TJ, Muise AM. Ghasempour S, et al. Among authors: upton jem. J Exp Med. 2024 Dec 2;221(12):e20240546. doi: 10.1084/jem.20240546. Epub 2024 Nov 11. J Exp Med. 2024. PMID: 39526957 Free PMC article.
495 results