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A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death.
Mannion J, Gifford V, Bellenie B, Fernando W, Ramos Garcia L, Wilson R, John SW, Udainiya S, Patin EC, Tiu C, Smith A, Goicoechea M, Craxton A, Moraes de Vasconcelos N, Guppy N, Cheung KJ, Cundy NJ, Pierrat O, Brennan A, Roumeliotis TI, Benstead-Hume G, Alexander J, Muirhead G, Layzell S, Lyu W, Roulstone V, Allen M, Baldock H, Legrand A, Gabel F, Serrano-Aparicio N, Starling C, Guo H, Upton J, Gyrd-Hansen M, MacFarlane M, Seddon B, Raynaud F, Roxanis I, Harrington K, Haider S, Choudhary JS, Hoelder S, Tenev T, Meier P. Mannion J, et al. Immunity. 2024 Jul 9;57(7):1514-1532.e15. doi: 10.1016/j.immuni.2024.04.025. Epub 2024 May 23. Immunity. 2024. PMID: 38788712 Free article.
Novel biochemical, structural, and systems insights into inflammatory signaling revealed by contextual interaction proteomics.
Ciuffa R, Uliana F, Mannion J, Mehnert M, Tenev T, Marulli C, Satanowski A, Keller LML, Rodilla Ramírez PN, Ori A, Gstaiger M, Meier P, Aebersold R. Ciuffa R, et al. Among authors: mannion j. Proc Natl Acad Sci U S A. 2022 Oct 4;119(40):e2117175119. doi: 10.1073/pnas.2117175119. Epub 2022 Sep 30. Proc Natl Acad Sci U S A. 2022. PMID: 36179048 Free PMC article.
Mef2d potentiates type-2 immune responses and allergic lung inflammation.
Szeto ACH, Clark PA, Ferreira ACF, Heycock M, Griffiths EL, Jou E, Mannion J, Luan SL, Storrar S, Knolle MD, Kozik P, Jolin HE, Fallon PG, McKenzie ANJ. Szeto ACH, et al. Among authors: mannion j. Science. 2024 Jun 28;384(6703):eadl0370. doi: 10.1126/science.adl0370. Epub 2024 Jun 28. Science. 2024. PMID: 38935708 Free PMC article.
Unresponsive patient with bradycardia.
Mannion J, Murray C, Wilkinson M. Mannion J, et al. Heart. 2024 Dec 13;111(1):17-44. doi: 10.1136/heartjnl-2024-324688. Heart. 2024. PMID: 39674589 No abstract available.
133 results