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A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death.
Mannion J, Gifford V, Bellenie B, Fernando W, Ramos Garcia L, Wilson R, John SW, Udainiya S, Patin EC, Tiu C, Smith A, Goicoechea M, Craxton A, Moraes de Vasconcelos N, Guppy N, Cheung KJ, Cundy NJ, Pierrat O, Brennan A, Roumeliotis TI, Benstead-Hume G, Alexander J, Muirhead G, Layzell S, Lyu W, Roulstone V, Allen M, Baldock H, Legrand A, Gabel F, Serrano-Aparicio N, Starling C, Guo H, Upton J, Gyrd-Hansen M, MacFarlane M, Seddon B, Raynaud F, Roxanis I, Harrington K, Haider S, Choudhary JS, Hoelder S, Tenev T, Meier P. Mannion J, et al. Among authors: benstead hume g. Immunity. 2024 Jul 9;57(7):1514-1532.e15. doi: 10.1016/j.immuni.2024.04.025. Epub 2024 May 23. Immunity. 2024. PMID: 38788712 Free article.
PIK3Cδ expression by fibroblasts promotes triple-negative breast cancer progression.
Gagliano T, Shah K, Gargani S, Lao L, Alsaleem M, Chen J, Ntafis V, Huang P, Ditsiou A, Vella V, Yadav K, Bienkowska K, Bresciani G, Kang K, Li L, Carter P, Benstead-Hume G, O'Hanlon T, Dean M, Pearl FM, Lee SC, Rakha EA, Green AR, Kontoyiannis DL, Song E, Stebbing J, Giamas G. Gagliano T, et al. Among authors: benstead hume g. J Clin Invest. 2020 Jun 1;130(6):3188-3204. doi: 10.1172/JCI128313. J Clin Invest. 2020. PMID: 32125284 Free PMC article.
Bioinformatics in translational drug discovery.
Wooller SK, Benstead-Hume G, Chen X, Ali Y, Pearl FMG. Wooller SK, et al. Among authors: benstead hume g. Biosci Rep. 2017 Jul 7;37(4):BSR20160180. doi: 10.1042/BSR20160180. Print 2017 Aug 31. Biosci Rep. 2017. PMID: 28487472 Free PMC article. Review.
14 results