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Gene therapy with phosphodiesterases 2A and 4B ameliorates heart failure and arrhythmias by improving subcellular cAMP compartmentation.
Pavlaki N, Froese A, Li W, De Jong KA, Geertz B, Subramanian H, Mohagaonkar S, Luo X, Schubert M, Wiegmann R, Margaria JP, Ghigo A, Kämmerer S, Hirsch E, El-Armouche A, Guan K, Nikolaev VO. Pavlaki N, et al. Among authors: wiegmann r. Cardiovasc Res. 2024 Jul 31;120(9):1011-1023. doi: 10.1093/cvr/cvae094. Cardiovasc Res. 2024. PMID: 38776406