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Page 1
Gene therapy with phosphodiesterases 2A and 4B ameliorates heart failure and arrhythmias by improving subcellular cAMP compartmentation.
Pavlaki N, Froese A, Li W, De Jong KA, Geertz B, Subramanian H, Mohagaonkar S, Luo X, Schubert M, Wiegmann R, Margaria JP, Ghigo A, Kämmerer S, Hirsch E, El-Armouche A, Guan K, Nikolaev VO. Pavlaki N, et al. Among authors: margaria jp. Cardiovasc Res. 2024 Jul 31;120(9):1011-1023. doi: 10.1093/cvr/cvae094. Cardiovasc Res. 2024. PMID: 38776406
Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer.
De Santis MC, Gozzelino L, Margaria JP, Costamagna A, Ratto E, Gulluni F, Di Gregorio E, Mina E, Lorito N, Bacci M, Lattanzio R, Sala G, Cappello P, Novelli F, Giovannetti E, Vicentini C, Andreani S, Delfino P, Corbo V, Scarpa A, Porporato PE, Morandi A, Hirsch E, Martini M. De Santis MC, et al. Among authors: margaria jp. Gut. 2023 Feb;72(2):360-371. doi: 10.1136/gutjnl-2021-325117. Epub 2022 May 27. Gut. 2023. PMID: 35623884 Free PMC article.
Phosphoinositide Conversion Inactivates R-RAS and Drives Metastases in Breast Cancer.
Li H, Prever L, Hsu MY, Lo WT, Margaria JP, De Santis MC, Zanini C, Forni M, Novelli F, Pece S, Di Fiore PP, Porporato PE, Martini M, Belabed H, Nazare M, Haucke V, Gulluni F, Hirsch E. Li H, et al. Among authors: margaria jp. Adv Sci (Weinh). 2022 Mar;9(9):e2103249. doi: 10.1002/advs.202103249. Epub 2022 Jan 31. Adv Sci (Weinh). 2022. PMID: 35098698 Free PMC article.
PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.
Gulluni F, Prever L, Li H, Krafcikova P, Corrado I, Lo WT, Margaria JP, Chen A, De Santis MC, Cnudde SJ, Fogerty J, Yuan A, Massarotti A, Sarijalo NT, Vadas O, Williams RL, Thelen M, Powell DR, Schueler M, Wiesener MS, Balla T, Baris HN, Tiosano D, McDermott BM Jr, Perkins BD, Ghigo A, Martini M, Haucke V, Boura E, Merlo GR, Buchner DA, Hirsch E. Gulluni F, et al. Among authors: margaria jp. Science. 2021 Dec 10;374(6573):eabk0410. doi: 10.1126/science.abk0410. Epub 2021 Dec 10. Science. 2021. PMID: 34882480 Free PMC article.
Response by Vandecasteele et al to Letter Regarding Article, "Cardiac Overexpression of PDE4B Blunts β-Adrenergic Response and Maladaptive Remodeling in Heart Failure".
Vandecasteele G, Mika D, Margaria JP, Ghigo A, Hirsch E, Leroy J, Fischmeister R. Vandecasteele G, et al. Among authors: margaria jp. Circulation. 2021 Jan 26;143(4):e26-e27. doi: 10.1161/CIRCULATIONAHA.120.051628. Epub 2021 Jan 25. Circulation. 2021. PMID: 33493025 No abstract available.
Cardiac Overexpression of PDE4B Blunts β-Adrenergic Response and Maladaptive Remodeling in Heart Failure.
Karam S, Margaria JP, Bourcier A, Mika D, Varin A, Bedioune I, Lindner M, Bouadjel K, Dessillons M, Gaudin F, Lefebvre F, Mateo P, Lechène P, Gomez S, Domergue V, Robert P, Coquard C, Algalarrondo V, Samuel JL, Michel JB, Charpentier F, Ghigo A, Hirsch E, Fischmeister R, Leroy J, Vandecasteele G. Karam S, et al. Among authors: margaria jp. Circulation. 2020 Jul 14;142(2):161-174. doi: 10.1161/CIRCULATIONAHA.119.042573. Epub 2020 Apr 8. Circulation. 2020. PMID: 32264695
21 results