Bedekovics T - Search Results

1

USP44 Overexpression Drives a MYC-Like Gene Expression Program in Neuroblastoma through Epigenetic Reprogramming.

Ekstrom TL, Hussain S, Bedekovics T, Ali A, Paolini L, Mahmood H, Rosok RM, Koster J, Johnsen SA, Galardy PJ. Ekstrom TL, et al. Among authors: bedekovics t. Mol Cancer Res. 2024 Sep 4;22(9):812-825. doi: 10.1158/1541-7786.MCR-23-0454. Mol Cancer Res. 2024. PMID: 38775808 Free PMC article.

2

UCH-L1 is induced in germinal center B cells and identifies patients with aggressive germinal center diffuse large B-cell lymphoma.

Bedekovics T, Hussain S, Feldman AL, Galardy PJ. Bedekovics T, et al. Blood. 2016 Mar 24;127(12):1564-74. doi: 10.1182/blood-2015-07-656678. Epub 2015 Dec 23. Blood. 2016. PMID: 26702068 Free PMC article.

3

USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor Suppressor, and Chromosome Instability Gene Deleted in Neuroblastoma.

Bedekovics T, Hussain S, Zhang Y, Ali A, Jeon YJ, Galardy PJ. Bedekovics T, et al. Cancer Res. 2021 Mar 1;81(5):1321-1331. doi: 10.1158/0008-5472.CAN-20-1777. Epub 2020 Dec 22. Cancer Res. 2021. PMID: 33355202

4

UCHL1 is a biomarker of aggressive multiple myeloma required for disease progression.

Hussain S, Bedekovics T, Chesi M, Bergsagel PL, Galardy PJ. Hussain S, et al. Among authors: bedekovics t. Oncotarget. 2015 Dec 1;6(38):40704-18. doi: 10.18632/oncotarget.5727. Oncotarget. 2015. PMID: 26513019 Free PMC article.

5

UCH-L1 bypasses mTOR to promote protein biosynthesis and is required for MYC-driven lymphomagenesis in mice.

Hussain S, Bedekovics T, Liu Q, Hu W, Jeon H, Johnson SH, Vasmatzis G, May DG, Roux KJ, Galardy PJ. Hussain S, et al. Among authors: bedekovics t. Blood. 2018 Dec 13;132(24):2564-2574. doi: 10.1182/blood-2018-05-848515. Epub 2018 Sep 26. Blood. 2018. PMID: 30257881 Free PMC article.

6

Walking the tightrope: UCH-L1 as an mTOR inhibitor and B-cell oncogene.

Bedekovics T, Hussain S, Galardy PJ. Bedekovics T, et al. Oncotarget. 2019 Aug 27;10(50):5124-5125. doi: 10.18632/oncotarget.27154. eCollection 2019 Aug 27. Oncotarget. 2019. PMID: 31497243 Free PMC article. No abstract available.

7

A cysteine near the C-terminus of UCH-L1 is dispensable for catalytic activity but is required to promote AKT phosphorylation, eIF4F assembly, and malignant B-cell survival.

Hussain S, Bedekovics T, Ali A, Zaid O, May DG, Roux KJ, Galardy PJ. Hussain S, et al. Among authors: bedekovics t. Cell Death Discov. 2019 Dec 10;5:152. doi: 10.1038/s41420-019-0231-1. eCollection 2019. Cell Death Discov. 2019. PMID: 31839994 Free PMC article.

8

Targeting childhood, adolescent and young adult non-Hodgkin lymphoma: therapeutic horizons.

Galardy PJ, Bedekovics T, Hermiston ML. Galardy PJ, et al. Among authors: bedekovics t. Br J Haematol. 2016 May;173(4):625-36. doi: 10.1111/bjh.14016. Epub 2016 Mar 27. Br J Haematol. 2016. PMID: 27019108 Free article. Review.

9

Lymphoma diagnostics: getting more from less.

Galardy PJ, Bedekovics T, Macintyre E, Miles RR. Galardy PJ, et al. Among authors: bedekovics t. Br J Haematol. 2019 Jun;185(6):1136-1141. doi: 10.1111/bjh.15788. Epub 2019 Feb 19. Br J Haematol. 2019. PMID: 30784044 Free article. Review.

10

Proximity Proteomics Reveals USP44 Forms a Complex with BRCA2 in Neuroblastoma Cells and Is Required to Prevent Chromosome Breakage.

Ali A, Hussain S, Bedekovics T, Jeon RH, May DG, Roux KJ, Galardy PJ. Ali A, et al. Among authors: bedekovics t. Biomedicines. 2024 Dec 20;12(12):2901. doi: 10.3390/biomedicines12122901. Biomedicines. 2024. PMID: 39767807 Free PMC article.

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