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Gut microbial β-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics.
Simpson JB, Walker ME, Sekela JJ, Ivey SM, Jariwala PB, Storch CM, Kowalewski ME, Graboski AL, Lietzan AD, Walton WG, Davis KA, Cloer EW, Borlandelli V, Hsiao YC, Roberts LR, Perlman DH, Liang X, Overkleeft HS, Bhatt AP, Lu K, Redinbo MR. Simpson JB, et al. Cell Host Microbe. 2024 Jun 12;32(6):925-944.e10. doi: 10.1016/j.chom.2024.04.018. Epub 2024 May 15. Cell Host Microbe. 2024. PMID: 38754417 Free article.
Discovering the Microbial Enzymes Driving Drug Toxicity with Activity-Based Protein Profiling.
Jariwala PB, Pellock SJ, Goldfarb D, Cloer EW, Artola M, Simpson JB, Bhatt AP, Walton WG, Roberts LR, Major MB, Davies GJ, Overkleeft HS, Redinbo MR. Jariwala PB, et al. Among authors: simpson jb. ACS Chem Biol. 2020 Jan 17;15(1):217-225. doi: 10.1021/acschembio.9b00788. Epub 2019 Dec 12. ACS Chem Biol. 2020. PMID: 31774274 Free PMC article.
Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract.
Zhang J, Walker ME, Sanidad KZ, Zhang H, Liang Y, Zhao E, Chacon-Vargas K, Yeliseyev V, Parsonnet J, Haggerty TD, Wang G, Simpson JB, Jariwala PB, Beaty VV, Yang J, Yang H, Panigrahy A, Minter LM, Kim D, Gibbons JG, Liu L, Li Z, Xiao H, Borlandelli V, Overkleeft HS, Cloer EW, Major MB, Goldfarb D, Cai Z, Redinbo MR, Zhang G. Zhang J, et al. Among authors: simpson jb. Nat Commun. 2022 Jan 10;13(1):136. doi: 10.1038/s41467-021-27762-y. Nat Commun. 2022. PMID: 35013263 Free PMC article.
Gut microbial β-glucuronidases regulate host luminal proteases and are depleted in irritable bowel syndrome.
Edwinson AL, Yang L, Peters S, Hanning N, Jeraldo P, Jagtap P, Simpson JB, Yang TY, Kumar P, Mehta S, Nair A, Breen-Lyles M, Chikkamenahalli L, Graham RP, De Winter B, Patel R, Dasari S, Kashyap P, Griffin T, Chen J, Farrugia G, Redinbo MR, Grover M. Edwinson AL, et al. Among authors: simpson jb. Nat Microbiol. 2022 May;7(5):680-694. doi: 10.1038/s41564-022-01103-1. Epub 2022 Apr 28. Nat Microbiol. 2022. PMID: 35484230 Free PMC article.
A structural metagenomics pipeline for examining the gut microbiome.
Walker ME, Simpson JB, Redinbo MR. Walker ME, et al. Among authors: simpson jb. Curr Opin Struct Biol. 2022 Aug;75:102416. doi: 10.1016/j.sbi.2022.102416. Epub 2022 Jul 13. Curr Opin Struct Biol. 2022. PMID: 35841748 Free PMC article. Review.
Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut.
Foley MH, Walker ME, Stewart AK, O'Flaherty S, Gentry EC, Patel S, Beaty VV, Allen G, Pan M, Simpson JB, Perkins C, Vanhoy ME, Dougherty MK, McGill SK, Gulati AS, Dorrestein PC, Baker ES, Redinbo MR, Barrangou R, Theriot CM. Foley MH, et al. Among authors: simpson jb. Nat Microbiol. 2023 Apr;8(4):611-628. doi: 10.1038/s41564-023-01337-7. Epub 2023 Mar 13. Nat Microbiol. 2023. PMID: 36914755 Free PMC article.
122 results