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A metabolite from commensal Candida albicans enhances the bactericidal activity of macrophages and protects against sepsis.
Gu P, Liu R, Yang Q, Xie L, Wei R, Li J, Mei F, Chen T, Zeng Z, He Y, Zhou H, Peng H, Nandakumar KS, Chu H, Jiang Y, Gong W, Chen Y, Schnabl B, Chen P. Gu P, et al. Among authors: li j. Cell Mol Immunol. 2023 Oct;20(10):1156-1170. doi: 10.1038/s41423-023-01070-5. Epub 2023 Aug 9. Cell Mol Immunol. 2023. PMID: 37553429 Free PMC article.
Gut-derived 4-hydroxyphenylacetic acid attenuates sepsis-induced acute kidney injury by upregulating ARC to inhibit necroptosis.
An S, Yao Y, Wu J, Hu H, Wu J, Sun M, Li J, Zhang Y, Li L, Qiu W, Li Y, Deng Z, Fang H, Gong S, Huang Q, Chen Z, Zeng Z. An S, et al. Among authors: li y, li j, li l. Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166876. doi: 10.1016/j.bbadis.2023.166876. Epub 2023 Sep 13. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 37714058
Gut commensal metabolite rhamnose promotes macrophages phagocytosis by activating SLC12A4 and protects against sepsis in mice.
Li D, Wei R, Zhang X, Gong S, Wan M, Wang F, Li J, Chen M, Liu R, Wan Y, Hong Y, Zeng Z, Gu P, Wang Z, Selva Nandakumar K, Jiang Y, Zhou H, Chen P. Li D, et al. Among authors: li j. Acta Pharm Sin B. 2024 Jul;14(7):3068-3085. doi: 10.1016/j.apsb.2024.03.025. Epub 2024 Mar 22. Acta Pharm Sin B. 2024. PMID: 39027244 Free PMC article.
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