Siddiqui G - Search Results

1

Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy.

Creek D, Giannangelo C, Challis M, Siddiqui G, Edgar R, Malcolm T, Webb C, Drinkwater N, Vinh N, MacRaild C, Counihan N, Duffy S, Wittlin S, Devine S, Avery V, de Koning-Ward T, Scammells P, McGowan S. Creek D, et al. Among authors: siddiqui g. Res Sq [Preprint]. 2024 Apr 26:rs.3.rs-3251230. doi: 10.21203/rs.3.rs-3251230/v3. Res Sq. 2024. Update in: Elife. 2024 Jul 08;13:RP92990. doi: 10.7554/eLife.92990 PMID: 38746424 Free PMC article. Updated. Preprint.

2

Bioinformatic prediction of the exportome of Babesia bovis and identification of novel proteins in parasite-infected red blood cells.

Gohil S, Kats LM, Seemann T, Fernandez KM, Siddiqui G, Cooke BM. Gohil S, et al. Among authors: siddiqui g. Int J Parasitol. 2013 Apr;43(5):409-16. doi: 10.1016/j.ijpara.2013.01.002. Epub 2013 Feb 8. Int J Parasitol. 2013. PMID: 23395698

3

Multi-omics Based Identification of Specific Biochemical Changes Associated With PfKelch13-Mutant Artemisinin-Resistant Plasmodium falciparum.

Siddiqui G, Srivastava A, Russell AS, Creek DJ. Siddiqui G, et al. J Infect Dis. 2017 May 1;215(9):1435-1444. doi: 10.1093/infdis/jix156. J Infect Dis. 2017. PMID: 28368494

4

Multi-omic Characterization of the Mode of Action of a Potent New Antimalarial Compound, JPC-3210, Against Plasmodium falciparum.

Birrell GW, Challis MP, De Paoli A, Anderson D, Devine SM, Heffernan GD, Jacobus DP, Edstein MD, Siddiqui G, Creek DJ. Birrell GW, et al. Among authors: siddiqui g. Mol Cell Proteomics. 2020 Feb;19(2):308-325. doi: 10.1074/mcp.RA119.001797. Epub 2019 Dec 13. Mol Cell Proteomics. 2020. PMID: 31836637 Free PMC article.

5

System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion.

Giannangelo C, Siddiqui G, De Paoli A, Anderson BM, Edgington-Mitchell LE, Charman SA, Creek DJ. Giannangelo C, et al. Among authors: siddiqui g. PLoS Pathog. 2020 Jun 26;16(6):e1008485. doi: 10.1371/journal.ppat.1008485. eCollection 2020 Jun. PLoS Pathog. 2020. PMID: 32589689 Free PMC article.

6

Discovery and development of 2-aminobenzimidazoles as potent antimalarials.

Devine SM, Challis MP, Kigotho JK, Siddiqui G, De Paoli A, MacRaild CA, Avery VM, Creek DJ, Norton RS, Scammells PJ. Devine SM, et al. Among authors: siddiqui g. Eur J Med Chem. 2021 Oct 5;221:113518. doi: 10.1016/j.ejmech.2021.113518. Epub 2021 May 13. Eur J Med Chem. 2021. PMID: 34058708

7

Peroxide Antimalarial Drugs Target Redox Homeostasis in Plasmodium falciparum Infected Red Blood Cells.

Siddiqui G, Giannangelo C, De Paoli A, Schuh AK, Heimsch KC, Anderson D, Brown TG, MacRaild CA, Wu J, Wang X, Dong Y, Vennerstrom JL, Becker K, Creek DJ. Siddiqui G, et al. ACS Infect Dis. 2022 Jan 14;8(1):210-226. doi: 10.1021/acsinfecdis.1c00550. Epub 2022 Jan 5. ACS Infect Dis. 2022. PMID: 34985858 Free PMC article.

8

A new mass spectral library for high-coverage and reproducible analysis of the Plasmodium falciparum-infected red blood cell proteome.

Siddiqui G, De Paoli A, MacRaild CA, Sexton AE, Boulet C, Shah AD, Batty MB, Schittenhelm RB, Carvalho TG, Creek DJ. Siddiqui G, et al. Gigascience. 2022 Mar 7;11:giac008. doi: 10.1093/gigascience/giac008. Gigascience. 2022. PMID: 35254426 Free PMC article.

9

Red Blood Cell BCL-x_L Is Required for Plasmodium falciparum Survival: Insights into Host-Directed Malaria Therapies.

Boulet C, Siddiqui G, Gaynor TL, Doerig C, Creek DJ, Carvalho TG. Boulet C, et al. Among authors: siddiqui g. Microorganisms. 2022 Apr 15;10(4):824. doi: 10.3390/microorganisms10040824. Microorganisms. 2022. PMID: 35456874 Free PMC article.

10

Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway.

Edgar RCS, Siddiqui G, Hjerrild K, Malcolm TR, Vinh NB, Webb CT, Holmes C, MacRaild CA, Chernih HC, Suen WW, Counihan NA, Creek DJ, Scammells PJ, McGowan S, de Koning-Ward TF. Edgar RCS, et al. Among authors: siddiqui g. Elife. 2022 Sep 13;11:e80813. doi: 10.7554/eLife.80813. Elife. 2022. PMID: 36097817 Free PMC article.

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