Arnold FH - Search Results

1

The β-subunit of tryptophan synthase is a latent tyrosine synthase.

Almhjell PJ, Johnston KE, Porter NJ, Kennemur JL, Bhethanabotla VC, Ducharme J, Arnold FH. Almhjell PJ, et al. Among authors: arnold fh. Nat Chem Biol. 2024 Aug;20(8):1086-1093. doi: 10.1038/s41589-024-01619-z. Epub 2024 May 14. Nat Chem Biol. 2024. PMID: 38744987 Free PMC article.

2

Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation.

Buller AR, Brinkmann-Chen S, Romney DK, Herger M, Murciano-Calles J, Arnold FH. Buller AR, et al. Among authors: arnold fh. Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14599-604. doi: 10.1073/pnas.1516401112. Epub 2015 Nov 9. Proc Natl Acad Sci U S A. 2015. PMID: 26553994 Free PMC article.

3

Synthesis of β-Branched Tryptophan Analogues Using an Engineered Subunit of Tryptophan Synthase.

Herger M, van Roye P, Romney DK, Brinkmann-Chen S, Buller AR, Arnold FH. Herger M, et al. Among authors: arnold fh. J Am Chem Soc. 2016 Jul 13;138(27):8388-91. doi: 10.1021/jacs.6b04836. Epub 2016 Jul 1. J Am Chem Soc. 2016. PMID: 27355405 Free PMC article.

4

Unlocking Reactivity of TrpB: A General Biocatalytic Platform for Synthesis of Tryptophan Analogues.

Romney DK, Murciano-Calles J, Wehrmüller JE, Arnold FH. Romney DK, et al. Among authors: arnold fh. J Am Chem Soc. 2017 Aug 9;139(31):10769-10776. doi: 10.1021/jacs.7b05007. Epub 2017 Jul 28. J Am Chem Soc. 2017. PMID: 28708383 Free PMC article.

5

Improved Synthesis of 4-Cyanotryptophan and Other Tryptophan Analogues in Aqueous Solvent Using Variants of TrpB from Thermotoga maritima.

Boville CE, Romney DK, Almhjell PJ, Sieben M, Arnold FH. Boville CE, et al. Among authors: arnold fh. J Org Chem. 2018 Jul 20;83(14):7447-7452. doi: 10.1021/acs.joc.8b00517. Epub 2018 Apr 27. J Org Chem. 2018. PMID: 29651849 Free PMC article.

6

Engineering enzymes for noncanonical amino acid synthesis.

Almhjell PJ , Boville CE , Arnold FH . Almhjell PJ , et al. Among authors: arnold fh. Chem Soc Rev. 2018 Dec 21;47(24):8980-8997. doi: 10.1039/c8cs00665b. Epub 2018 Oct 3. Chem Soc Rev. 2018. PMID: 30280154 Free PMC article. Review.

7

Enzymatic assembly of carbon-carbon bonds via iron-catalysed sp³ C-H functionalization.

Zhang RK, Chen K, Huang X, Wohlschlager L, Renata H, Arnold FH. Zhang RK, et al. Among authors: arnold fh. Nature. 2019 Jan;565(7737):67-72. doi: 10.1038/s41586-018-0808-5. Epub 2018 Dec 19. Nature. 2019. PMID: 30568304 Free PMC article.

8

Direct Enzymatic Synthesis of a Deep-Blue Fluorescent Noncanonical Amino Acid from Azulene and Serine.

Watkins EJ, Almhjell PJ, Arnold FH. Watkins EJ, et al. Among authors: arnold fh. Chembiochem. 2020 Jan 15;21(1-2):80-83. doi: 10.1002/cbic.201900497. Epub 2019 Nov 18. Chembiochem. 2020. PMID: 31513332 Free PMC article.

9

Tailoring Tryptophan Synthase TrpB for Selective Quaternary Carbon Bond Formation.

Dick M, Sarai NS, Martynowycz MW, Gonen T, Arnold FH. Dick M, et al. Among authors: arnold fh. J Am Chem Soc. 2019 Dec 18;141(50):19817-19822. doi: 10.1021/jacs.9b09864. Epub 2019 Dec 6. J Am Chem Soc. 2019. PMID: 31747522 Free PMC article.

10

Tryptophan Synthase: Biocatalyst Extraordinaire.

Watkins-Dulaney E, Straathof S, Arnold F. Watkins-Dulaney E, et al. Chembiochem. 2021 Jan 5;22(1):5-16. doi: 10.1002/cbic.202000379. Epub 2020 Sep 22. Chembiochem. 2021. PMID: 32677310 Free PMC article. Review.

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