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Page 1
A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants.
Ferreira LT, Cassiano GC, Alvarez LCS, Okombo J, Calit J, Fontinha D, Gil-Iturbe E, Coyle R, Andrade CH, Sunnerhagen P, Bargieri DY, Prudêncio M, Quick M, Cravo PV, Lee MCS, Fidock DA, Costa FTM. Ferreira LT, et al. Among authors: gil iturbe e. PLoS Pathog. 2024 Oct 29;20(10):e1012627. doi: 10.1371/journal.ppat.1012627. eCollection 2024 Oct. PLoS Pathog. 2024. PMID: 39471233 Free PMC article.
Identification of the drug/metabolite transporter 1 as a marker of quinine resistance in a NF54×Cam3.II P. falciparum genetic cross.
Kanai M, Mok S, Yeo T, Shears MJ, Ross LS, Jeon JH, Narwal S, Haile MT, Tripathi AK, Mlambo G, Kim J, Gil-Iturbe E, Okombo J, Fairhurst KJ, Bloxham T, Bridgford JL, Sheth T, Ward KE, Park H, Rozenberg FD, Quick M, Mancia F, Lee MCS, Small-Saunders JL, Uhlemann AC, Sinnis P, Fidock DA. Kanai M, et al. Among authors: gil iturbe e. bioRxiv [Preprint]. 2024 Oct 1:2024.09.27.615529. doi: 10.1101/2024.09.27.615529. bioRxiv. 2024. PMID: 39386571 Free PMC article. Preprint.
The glucose transporter GLUT12, a new actor in obesity and cancer.
Burgos M, Gil-Iturbe E, Idoate-Bayón A, Castilla-Madrigal R, Moreno-Aliaga MJ, Lostao MP. Burgos M, et al. Among authors: gil iturbe e. J Physiol Biochem. 2024 May 10. doi: 10.1007/s13105-024-01028-9. Online ahead of print. J Physiol Biochem. 2024. PMID: 38727993 Review.
Structural and molecular basis of choline uptake into the brain by FLVCR2.
Cater RJ, Mukherjee D, Gil-Iturbe E, Erramilli SK, Chen T, Koo K, Santander N, Reckers A, Kloss B, Gawda T, Choy BC, Zhang Z, Katewa A, Larpthaveesarp A, Huang EJ, Mooney SWJ, Clarke OB, Yee SW, Giacomini KM, Kossiakoff AA, Quick M, Arnold T, Mancia F. Cater RJ, et al. Among authors: gil iturbe e. Nature. 2024 May;629(8012):704-709. doi: 10.1038/s41586-024-07326-y. Epub 2024 May 1. Nature. 2024. PMID: 38693257
Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology.
Hagenah LM, Dhingra SK, Small-Saunders JL, Qahash T, Willems A, Schindler KA, Rangel GW, Gil-Iturbe E, Kim J, Akhundova E, Yeo T, Okombo J, Mancia F, Quick M, Roepe PD, Llinás M, Fidock DA. Hagenah LM, et al. Among authors: gil iturbe e. mBio. 2024 Jan 16;15(1):e0183223. doi: 10.1128/mbio.01832-23. Epub 2023 Dec 7. mBio. 2024. PMID: 38059639 Free PMC article.
Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness.
Mok S, Yeo T, Hong D, Shears MJ, Ross LS, Ward KE, Dhingra SK, Kanai M, Bridgford JL, Tripathi AK, Mlambo G, Burkhard AY, Ansbro MR, Fairhurst KJ, Gil-Iturbe E, Park H, Rozenberg FD, Kim J, Mancia F, Fairhurst RM, Quick M, Uhlemann AC, Sinnis P, Fidock DA. Mok S, et al. Among authors: gil iturbe e. Sci Adv. 2023 Nov 10;9(45):eadi2364. doi: 10.1126/sciadv.adi2364. Epub 2023 Nov 8. Sci Adv. 2023. PMID: 37939186 Free PMC article.
Insight into the mechanism of H+-coupled nucleobase transport.
Weng J, Zhou X, Wiriyasermkul P, Ren Z, Chen K, Gil-Iturbe E, Zhou M, Quick M. Weng J, et al. Among authors: gil iturbe e. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2302799120. doi: 10.1073/pnas.2302799120. Epub 2023 Aug 7. Proc Natl Acad Sci U S A. 2023. PMID: 37549264 Free PMC article.
Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness.
Mok S, Yeo T, Hong D, Shears MJ, Ross LS, Ward KE, Dhingra SK, Kanai M, Bridgford JL, Tripathi AK, Mlambo G, Burkhard AY, Fairhurst KJ, Gil-Iturbe E, Park H, Rozenberg FD, Kim J, Mancia F, Quick M, Uhlemann AC, Sinnis P, Fidock DA. Mok S, et al. Among authors: gil iturbe e. bioRxiv [Preprint]. 2023 Jun 3:2023.06.02.543338. doi: 10.1101/2023.06.02.543338. bioRxiv. 2023. Update in: Sci Adv. 2023 Nov 10;9(45):eadi2364. doi: 10.1126/sciadv.adi2364. PMID: 37398288 Free PMC article. Updated. Preprint.
24 results