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Epithelial sodium channels are activated by furin-dependent proteolysis.
Hughey RP, Bruns JB, Kinlough CL, Harkleroad KL, Tong Q, Carattino MD, Johnson JP, Stockand JD, Kleyman TR. Hughey RP, et al. Among authors: carattino md. J Biol Chem. 2004 Apr 30;279(18):18111-4. doi: 10.1074/jbc.C400080200. Epub 2004 Mar 7. J Biol Chem. 2004. PMID: 15007080 Free article.
Furin cleavage activates the epithelial Na+ channel by relieving Na+ self-inhibition.
Sheng S, Carattino MD, Bruns JB, Hughey RP, Kleyman TR. Sheng S, et al. Among authors: carattino md. Am J Physiol Renal Physiol. 2006 Jun;290(6):F1488-96. doi: 10.1152/ajprenal.00439.2005. Epub 2006 Jan 31. Am J Physiol Renal Physiol. 2006. PMID: 16449353 Free article.
We previously demonstrated that mutation of key residues within two furin cleavage consensus sites in alpha, or one site in gamma, blocked subunit proteolysis and inhibited channel activity when mutant channels were expressed in Xenopus laevis oocytes (Hughey RP, Bruns JB, Kinlou …
We previously demonstrated that mutation of key residues within two furin cleavage consensus sites in alpha, or one site in gamma, blocked s …
78 results