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TCR/CD3-based synthetic antigen receptors (TCC) convey superior antigen sensitivity combined with high fidelity of activation.
Mühlgrabner V, Peters T, Velasco Cárdenas RM, Salzer B, Göhring J, Plach A, Höhrhan M, Perez ID, Goncalves VDR, Farfán JS, Lehner M, Stockinger H, Schamel WW, Schober K, Busch DH, Hudecek M, Dushek O, Minguet S, Platzer R, Huppa JB. Mühlgrabner V, et al. Among authors: dushek o. Sci Adv. 2024 Sep 6;10(36):eadj4632. doi: 10.1126/sciadv.adj4632. Epub 2024 Sep 4. Sci Adv. 2024. PMID: 39231214 Free PMC article.
G6b-B antibody-based cis-acting platelet receptor inhibitors (CAPRIs) as a new family of anti-thrombotic therapeutics.
Mazharian A, Bertin O, Sarkar A, Augros J, Bornert A, Loubière C, Jönsson F, Warwicker J, Abbott WM, Dushek O, Vayne C, Rauova L, Fütterer K, Rollin J, Poncz M, Senis YA. Mazharian A, et al. Among authors: dushek o. bioRxiv [Preprint]. 2024 May 14:2024.05.10.593500. doi: 10.1101/2024.05.10.593500. bioRxiv. 2024. PMID: 38798354 Free PMC article. Preprint.
A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity.
Liu C, Zhou D, Dijokaite-Guraliuc A, Supasa P, Duyvesteyn HME, Ginn HM, Selvaraj M, Mentzer AJ, Das R, de Silva TI, Ritter TG, Plowright M, Newman TAH, Stafford L, Kronsteiner B, Temperton N, Lui Y, Fellermeyer M, Goulder P, Klenerman P, Dunachie SJ, Barton MI, Kutuzov MA, Dushek O; OPTIC Consortium; Fry EE, Mongkolsapaya J, Ren J, Stuart DI, Screaton GR. Liu C, et al. Among authors: dushek o. Cell Rep Med. 2024 May 21;5(5):101553. doi: 10.1016/j.xcrm.2024.101553. Epub 2024 May 8. Cell Rep Med. 2024. PMID: 38723626 Free PMC article.
Using CombiCells, a platform for titration and combinatorial display of cell surface ligands, to study T-cell antigen sensitivity modulation by accessory receptors.
Patel A, Andre V, Eguiguren SB, Barton MI, Burton J, Denham EM, Pettmann J, Mørch AM, Kutuzov MA, Siller-Farfán JA, Dustin ML, van der Merwe PA, Dushek O. Patel A, et al. Among authors: dushek o. EMBO J. 2024 Jan;43(1):132-150. doi: 10.1038/s44318-023-00012-1. Epub 2023 Dec 18. EMBO J. 2024. PMID: 38177315 Free PMC article.
Tuning the potency and selectivity of ImmTAC molecules by affinity modulation.
Robertson IB, Mulvaney R, Dieckmann N, Vantellini A, Canestraro M, Amicarella F, O'Dwyer R, Cole DK, Harper S, Dushek O, Kirk P. Robertson IB, et al. Among authors: dushek o. Clin Exp Immunol. 2024 Feb 7;215(2):105-119. doi: 10.1093/cei/uxad120. Clin Exp Immunol. 2024. PMID: 37930865 Free PMC article.
67 results