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Neuronal non-CG methylation is an essential target for MeCP2 function.
Tillotson R, Cholewa-Waclaw J, Chhatbar K, Connelly JC, Kirschner SA, Webb S, Koerner MV, Selfridge J, Kelly DA, De Sousa D, Brown K, Lyst MJ, Kriaucionis S, Bird A. Tillotson R, et al. Among authors: bird a. Mol Cell. 2021 Mar 18;81(6):1260-1275.e12. doi: 10.1016/j.molcel.2021.01.011. Epub 2021 Feb 8. Mol Cell. 2021. PMID: 33561390 Free PMC article.
Radically truncated MeCP2 rescues Rett syndrome-like neurological defects.
Tillotson R, Selfridge J, Koerner MV, Gadalla KKE, Guy J, De Sousa D, Hector RD, Cobb SR, Bird A. Tillotson R, et al. Among authors: bird a. Nature. 2017 Oct 19;550(7676):398-401. doi: 10.1038/nature24058. Epub 2017 Oct 11. Nature. 2017. PMID: 29019980 Free PMC article.
SALL4 controls cell fate in response to DNA base composition.
Pantier R, Chhatbar K, Quante T, Skourti-Stathaki K, Cholewa-Waclaw J, Alston G, Alexander-Howden B, Lee HY, Cook AG, Spruijt CG, Vermeulen M, Selfridge J, Bird A. Pantier R, et al. Among authors: bird a. Mol Cell. 2021 Feb 18;81(4):845-858.e8. doi: 10.1016/j.molcel.2020.11.046. Epub 2021 Jan 5. Mol Cell. 2021. PMID: 33406384 Free PMC article.
Absence of MeCP2 binding to non-methylated GT-rich sequences in vivo.
Connelly JC, Cholewa-Waclaw J, Webb S, Steccanella V, Waclaw B, Bird A. Connelly JC, et al. Among authors: bird a. Nucleic Acids Res. 2020 Apr 17;48(7):3542-3552. doi: 10.1093/nar/gkaa102. Nucleic Acids Res. 2020. PMID: 32064528 Free PMC article.
1,449 results