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Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis.
Himmelbauer MK, Bajrami B, Basile R, Capacci A, Chen T, Choi CK, Gilfillan R, Gonzalez-Lopez de Turiso F, Gu C, Hoemberger M, Johnson DS, Jones JH, Kadakia E, Kirkland M, Lin EY, Liu Y, Ma B, Magee T, Mantena S, Marx IE, Metrick CM, Mingueneau M, Murugan P, Muste CA, Nadella P, Nevalainen M, Parker Harp CR, Pattaropong V, Pietrasiewicz A, Prince RJ, Purgett TJ, Santoro JC, Schulz J, Sciabola S, Tang H, Vandeveer HG, Wang T, Yousaf Z, Helal CJ, Hopkins BT. Himmelbauer MK, et al. Among authors: lin ey. J Med Chem. 2024 May 23;67(10):8122-8140. doi: 10.1021/acs.jmedchem.4c00220. Epub 2024 May 7. J Med Chem. 2024. PMID: 38712838 Free PMC article.
Stereochemistry-activity relationship of orally active tetralin S1P agonist prodrugs.
Ma B, Guckian KM, Lin EY, Lee WC, Scott D, Kumaravel G, Macdonald TL, Lynch KR, Black C, Chollate S, Hahm K, Hetu G, Jin P, Luo Y, Rohde E, Rossomando A, Scannevin R, Wang J, Yang C. Ma B, et al. Among authors: lin ey. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2264-9. doi: 10.1016/j.bmcl.2010.02.006. Epub 2010 Feb 6. Bioorg Med Chem Lett. 2010. PMID: 20188554 Free PMC article.
Pyrazolone based TGFbetaR1 kinase inhibitors.
Guckian K, Carter MB, Lin EY, Choi M, Sun L, Boriack-Sjodin PA, Chuaqui C, Lane B, Cheung K, Ling L, Lee WC. Guckian K, et al. Among authors: lin ey. Bioorg Med Chem Lett. 2010 Jan 1;20(1):326-9. doi: 10.1016/j.bmcl.2009.10.108. Epub 2009 Oct 29. Bioorg Med Chem Lett. 2010. PMID: 19914068
Development of a PET Tracer for OGA with Improved Kinetics in the Living Brain.
Cook BE, Nag S, Arakawa R, Lin EY, Stratman N, Guckian K, Hering H, Lulla M, Choi J, Salinas C, Genung NE, Morén AF, Bolin M, Boscutti G, Plisson C, Martarello L, Halldin C, Kaliszczak MA. Cook BE, et al. Among authors: lin ey. J Nucl Med. 2023 Oct;64(10):1588-1593. doi: 10.2967/jnumed.122.265225. Epub 2023 Jul 6. J Nucl Med. 2023. PMID: 37934021 Free article.
N-terminally PEGylated human interferon-beta-1a with improved pharmacokinetic properties and in vivo efficacy in a melanoma angiogenesis model.
Baker DP, Lin EY, Lin K, Pellegrini M, Petter RC, Chen LL, Arduini RM, Brickelmaier M, Wen D, Hess DM, Chen L, Grant D, Whitty A, Gill A, Lindner DJ, Pepinsky RB. Baker DP, et al. Among authors: lin ey, lin k. Bioconjug Chem. 2006 Jan-Feb;17(1):179-88. doi: 10.1021/bc050237q. Bioconjug Chem. 2006. PMID: 16417267
146 results