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Page 1
Contrasting consequences of podocyte insulin-like growth factor 1 receptor inhibition.
Hurcombe JA, Barrington F, Marchetti M, Betin VMS, Bowen EE, Lay AC, Ni L, Dayalan L, Pope RJP, Brinkkoetter PT, Holzenberger M, Welsh GI, Coward RJM. Hurcombe JA, et al. Among authors: pope rjp. iScience. 2024 Apr 16;27(5):109749. doi: 10.1016/j.isci.2024.109749. eCollection 2024 May 17. iScience. 2024. PMID: 38706850 Free PMC article.
Shiga toxin targets the podocyte causing hemolytic uremic syndrome through endothelial complement activation.
Bowen EE, Hurcombe JA, Barrington F, Keir LS, Farmer LK, Wherlock MD, Ortiz-Sandoval CG, Bruno V, Bohorquez-Hernandez A, Diatlov D, Rostam-Shirazi N, Wells S, Stewart M, Teboul L, Lay AC, Butler MJ, Pope RJP, Larkai EMS, Morgan BP, Moppett J, Satchell SC, Welsh GI, Walker PD, Licht C, Saleem MA, Coward RJM. Bowen EE, et al. Among authors: pope rjp. Med. 2023 Nov 10;4(11):761-777.e8. doi: 10.1016/j.medj.2023.09.002. Epub 2023 Oct 19. Med. 2023. PMID: 37863058 Free article.
Profiling of insulin-resistant kidney models and human biopsies reveals common and cell-type-specific mechanisms underpinning Diabetic Kidney Disease.
Lay AC, Tran VDT, Nair V, Betin V, Hurcombe JA, Barrington AF, Pope RJ, Burdet F, Mehl F, Kryvokhyzha D, Ahmad A, Sinton MC, Lewis P, Wilson MC, Menon R, Otto E, Heesom KJ, Ibberson M, Looker HC, Nelson RG, Ju W, Kretzler M, Satchell SC, Gomez MF, Coward RJM; BEAt-DKD consortium. Lay AC, et al. Nat Commun. 2024 Nov 19;15(1):10018. doi: 10.1038/s41467-024-54089-1. Nat Commun. 2024. PMID: 39562547 Free PMC article.
IGFBP-1 expression is reduced in human type 2 diabetic glomeruli and modulates β1-integrin/FAK signalling in human podocytes.
Lay AC, Hale LJ, Stowell-Connolly H, Pope RJP, Nair V, Ju W, Marquez E, Rollason R, Hurcombe JA, Hayes B, Roberts T, Gillam L, Allington J, Nelson RG, Kretzler M, Holly JMP, Perks CM, McArdle CA, Welsh GI, Coward RJM. Lay AC, et al. Among authors: pope rjp. Diabetologia. 2021 Jul;64(7):1690-1702. doi: 10.1007/s00125-021-05427-1. Epub 2021 Mar 24. Diabetologia. 2021. PMID: 33758952 Free PMC article.