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The anti-leprosy drug clofazimine reduces polyQ toxicity through activation of PPARγ.
Li X, Hernandez I, Koyuncu S, Kis B, Häggblad M, Lidemalm L, Abbas AA, Bendegúz S, Göblös A, Brautigam L, Lucas JJ, Carreras-Puigvert J, Hühn D, Pircs K, Vilchez D, Fernandez-Capetillo O. Li X, et al. Among authors: lucas jj. EBioMedicine. 2024 May;103:105124. doi: 10.1016/j.ebiom.2024.105124. Epub 2024 May 2. EBioMedicine. 2024. PMID: 38701619 Free PMC article.
Faulty splicing and cytoskeleton abnormalities in Huntington's disease.
Fernández-Nogales M, Santos-Galindo M, Hernández IH, Cabrera JR, Lucas JJ. Fernández-Nogales M, et al. Among authors: lucas jj. Brain Pathol. 2016 Nov;26(6):772-778. doi: 10.1111/bpa.12430. Brain Pathol. 2016. PMID: 27529534 Free PMC article. Review.
The neuroprotective transcription factor ATF5 is decreased and sequestered into polyglutamine inclusions in Huntington's disease.
Hernández IH, Torres-Peraza J, Santos-Galindo M, Ramos-Morón E, Fernández-Fernández MR, Pérez-Álvarez MJ, Miranda-Vizuete A, Lucas JJ. Hernández IH, et al. Among authors: lucas jj. Acta Neuropathol. 2017 Dec;134(6):839-850. doi: 10.1007/s00401-017-1770-2. Epub 2017 Aug 31. Acta Neuropathol. 2017. PMID: 28861715 Free article.
Differential regulation of Kidins220 isoforms in Huntington's disease.
Sebastián-Serrano Á, Simón-García A, Belmonte-Alfaro A, Pose-Utrilla J, Santos-Galindo M, Del Puerto A, García-Guerra L, Hernández IH, Schiavo G, Campanero MR, Lucas JJ, Iglesias T. Sebastián-Serrano Á, et al. Among authors: lucas jj. Brain Pathol. 2020 Jan;30(1):120-136. doi: 10.1111/bpa.12761. Epub 2019 Jul 16. Brain Pathol. 2020. PMID: 31264746 Free PMC article.
Huntingtin-mediated axonal transport requires arginine methylation by PRMT6.
Migazzi A, Scaramuzzino C, Anderson EN, Tripathy D, Hernández IH, Grant RA, Roccuzzo M, Tosatto L, Virlogeux A, Zuccato C, Caricasole A, Ratovitski T, Ross CA, Pandey UB, Lucas JJ, Saudou F, Pennuto M, Basso M. Migazzi A, et al. Among authors: lucas jj. Cell Rep. 2021 Apr 13;35(2):108980. doi: 10.1016/j.celrep.2021.108980. Cell Rep. 2021. PMID: 33852844 Free PMC article.
A new non-aggregative splicing isoform of human Tau is decreased in Alzheimer's disease.
García-Escudero V, Ruiz-Gabarre D, Gargini R, Pérez M, García E, Cuadros R, Hernández IH, Cabrera JR, García-Escudero R, Lucas JJ, Hernández F, Ávila J. García-Escudero V, et al. Among authors: lucas jj. Acta Neuropathol. 2021 Jul;142(1):159-177. doi: 10.1007/s00401-021-02317-z. Epub 2021 May 2. Acta Neuropathol. 2021. PMID: 33934221 Free PMC article.
CPEB alteration and aberrant transcriptome-polyadenylation lead to a treatable SLC19A3 deficiency in Huntington's disease.
Picó S, Parras A, Santos-Galindo M, Pose-Utrilla J, Castro M, Fraga E, Hernández IH, Elorza A, Anta H, Wang N, Martí-Sánchez L, Belloc E, Garcia-Esparcia P, Garrido JJ, Ferrer I, Macías-García D, Mir P, Artuch R, Pérez B, Hernández F, Navarro P, López-Sendón JL, Iglesias T, Yang XW, Méndez R, Lucas JJ. Picó S, et al. Among authors: lucas jj. Sci Transl Med. 2021 Sep 29;13(613):eabe7104. doi: 10.1126/scitranslmed.abe7104. Epub 2021 Sep 29. Sci Transl Med. 2021. PMID: 34586830 Free article.
284 results