Brabet I - Search Results

1

Novel Inhibitory Site Revealed by XAP044 Mode of Action on the Metabotropic Glutamate 7 Receptor Venus Flytrap Domain.

Cristiano N, Cabayé A, Brabet I, Glatthar R, Tora A, Goudet C, Bertrand HO, Goupil-Lamy A, Flor PJ, Pin JP, McCort-Tranchepain I, Acher FC. Cristiano N, et al. Among authors: brabet i. J Med Chem. 2024 Jul 25;67(14):11662-11687. doi: 10.1021/acs.jmedchem.3c01924. Epub 2024 May 1. J Med Chem. 2024. PMID: 38691510 Free article.

2

Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes.

Acher FC, Tellier FJ, Azerad R, Brabet IN, Fagni L, Pin JP. Acher FC, et al. Among authors: brabet in. J Med Chem. 1997 Sep 12;40(19):3119-29. doi: 10.1021/jm970207b. J Med Chem. 1997. PMID: 9301676

3

Virtual screening workflow development guided by the "receiver operating characteristic" curve approach. Application to high-throughput docking on metabotropic glutamate receptor subtype 4.

Triballeau N, Acher F, Brabet I, Pin JP, Bertrand HO. Triballeau N, et al. Among authors: brabet i. J Med Chem. 2005 Apr 7;48(7):2534-47. doi: 10.1021/jm049092j. J Med Chem. 2005. PMID: 15801843

4

Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists.

Sibille P, Lopez S, Brabet I, Valenti O, Oueslati N, Gaven F, Goudet C, Bertrand HO, Neyton J, Marino MJ, Amalric M, Pin JP, Acher FC. Sibille P, et al. Among authors: brabet i. J Med Chem. 2007 Jul 26;50(15):3585-95. doi: 10.1021/jm070262c. Epub 2007 Jun 28. J Med Chem. 2007. PMID: 17602546

5

A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists.

Selvam C, Oueslati N, Lemasson IA, Brabet I, Rigault D, Courtiol T, Cesarini S, Triballeau N, Bertrand HO, Goudet C, Pin JP, Acher FC. Selvam C, et al. Among authors: brabet i. J Med Chem. 2010 Apr 8;53(7):2797-813. doi: 10.1021/jm901523t. J Med Chem. 2010. PMID: 20218620

6

Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites.

Selvam C, Lemasson IA, Brabet I, Oueslati N, Karaman B, Cabaye A, Tora AS, Commare B, Courtiol T, Cesarini S, McCort-Tranchepain I, Rigault D, Mony L, Bessiron T, McLean H, Leroux FR, Colobert F, Daniel H, Goupil-Lamy A, Bertrand HO, Goudet C, Pin JP, Acher FC. Selvam C, et al. Among authors: brabet i. J Med Chem. 2018 Mar 8;61(5):1969-1989. doi: 10.1021/acs.jmedchem.7b01438. Epub 2018 Feb 14. J Med Chem. 2018. PMID: 29397723

7

Design, Synthesis, Pharmacology, and In Silico Studies of (1S,2S,3S)-2-((S)-Amino(carboxy)methyl)-3-(carboxymethyl)cyclopropane-1-carboxylic Acid (LBG30300): A Picomolar Potency Subtype-Selective mGlu₂ Receptor Agonist.

Liu N, Eshak F, Malhaire F, Brabet I, Prézeau L, Renard E, Pin JP, Acher FC, Staudt M, Bunch L. Liu N, et al. Among authors: brabet i. J Med Chem. 2024 Jan 25;67(2):1314-1326. doi: 10.1021/acs.jmedchem.3c01811. Epub 2024 Jan 3. J Med Chem. 2024. PMID: 38170918 Free article.

8

Aminobicyclo[2.2.1.]heptane dicarboxylic acids (ABHD), rigid analogs of ACPD and glutamic acid: synthesis and pharmacological activity on metabotropic receptors mGluR1 and mGluR2.

Tellier F, Acher F, Brabet I, Pin JP, Azerad R. Tellier F, et al. Among authors: brabet i. Bioorg Med Chem. 1998 Feb;6(2):195-208. doi: 10.1016/s0968-0896(97)10031-1. Bioorg Med Chem. 1998. PMID: 9547943

9

Agonist selectivity of mGluR1 and mGluR2 metabotropic receptors: a different environment but similar recognition of an extended glutamate conformation.

Jullian N, Brabet I, Pin JP, Acher FC. Jullian N, et al. Among authors: brabet i. J Med Chem. 1999 May 6;42(9):1546-55. doi: 10.1021/jm980571q. J Med Chem. 1999. PMID: 10229625

10

Closure of the Venus flytrap module of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists.

Bessis AS, Rondard P, Gaven F, Brabet I, Triballeau N, Prezeau L, Acher F, Pin JP. Bessis AS, et al. Among authors: brabet i. Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11097-102. doi: 10.1073/pnas.162138699. Epub 2002 Jul 31. Proc Natl Acad Sci U S A. 2002. PMID: 12151600 Free PMC article.

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