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Page 1
A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19.
Allerton CMN, Arcari JT, Aschenbrenner LM, Avery M, Bechle BM, Behzadi MA, Boras B, Buzon LM, Cardin RD, Catlin NR, Carlo AA, Coffman KJ, Dantonio A, Di L, Eng H, Farley KA, Ferre RA, Gernhardt SS, Gibson SA, Greasley SE, Greenfield SR, Hurst BL, Kalgutkar AS, Kimoto E, Lanyon LF, Lovett GH, Lian Y, Liu W, Martínez Alsina LA, Noell S, Obach RS, Owen DR, Patel NC, Rai DK, Reese MR, Rothan HA, Sakata S, Sammons MF, Sathish JG, Sharma R, Steppan CM, Tuttle JB, Verhoest PR, Wei L, Yang Q, Yurgelonis I, Zhu Y. Allerton CMN, et al. Among authors: gernhardt ss. J Med Chem. 2024 Aug 22;67(16):13550-13571. doi: 10.1021/acs.jmedchem.3c02469. Epub 2024 Apr 30. J Med Chem. 2024. PMID: 38687966 Free PMC article.
Quantitative Translational Analysis of Brain Kynurenic Acid Modulation via Irreversible Kynurenine Aminotransferase II Inhibition.
Chang C, Fonseca KR, Li C, Horner W, Zawadzke LE, Salafia MA, Welch KA, Strick CA, Campbell BM, Gernhardt SS, Rong H, Sawant-Basak A, Liras J, Dounay A, Tuttle JB, Verhoest P, Maurer TS. Chang C, et al. Among authors: gernhardt ss. Mol Pharmacol. 2018 Aug;94(2):823-833. doi: 10.1124/mol.118.111625. Epub 2018 May 31. Mol Pharmacol. 2018. PMID: 29853495
BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice.
Bollinger E, Peloquin M, Libera J, Albuquerque B, Pashos E, Shipstone A, Hadjipanayis A, Sun Z, Xing G, Clasquin M, Stansfield JC, Tierney B, Gernhardt S, Siddall CP, Greizer T, Geoly FJ, Vargas SR, Gao LC, Williams G, Marshall M, Rosado A, Steppan C, Filipski KJ, Zhang BB, Miller RA, Roth Flach RJ. Bollinger E, et al. Mol Metab. 2022 Dec;66:101611. doi: 10.1016/j.molmet.2022.101611. Epub 2022 Oct 8. Mol Metab. 2022. PMID: 36220546 Free PMC article.