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Inhibiting Hippo pathway kinases releases WWC1 to promote AMPAR-dependent synaptic plasticity and long-term memory in mice.
Stepan J, Heinz DE, Dethloff F, Wiechmann S, Martinelli S, Hafner K, Ebert T, Junglas E, Häusl AS, Pöhlmann ML, Jakovcevski M, Pape JC, Zannas AS, Bajaj T, Hermann A, Ma X, Pavenstädt H, Schmidt MV, Philipsen A, Turck CW, Deussing JM, Rammes G, Robinson AC, Payton A, Wehr MC, Stein V, Murgatroyd C, Kremerskothen J, Kuster B, Wotjak CT, Gassen NC. Stepan J, et al. Among authors: hausl as. Sci Signal. 2024 Apr 30;17(834):eadj6603. doi: 10.1126/scisignal.adj6603. Epub 2024 Apr 30. Sci Signal. 2024. PMID: 38687825
Hippo-released WWC1 facilitates AMPA receptor regulatory complexes for hippocampal learning.
Stepan J, Heinz DE, Dethloff F, Bajaj T, Zellner A, Hafner K, Wiechmann S, Mackert S, Mecdad Y, Rabenstein M, Ebert T, Martinelli S, Häusl AS, Pöhlmann ML, Hermann A, Ma X, Pavenstädt H, Schmidt MV, Philipsen A, Turck CW, Deussing JM, Kuster B, Wehr MC, Stein V, Kremerskothen J, Wotjak CT, Gassen NC. Stepan J, et al. Among authors: hausl as. Cell Rep. 2022 Dec 6;41(10):111766. doi: 10.1016/j.celrep.2022.111766. Cell Rep. 2022. PMID: 36476872 Free article.
Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function.
Balsevich G, Häusl AS, Meyer CW, Karamihalev S, Feng X, Pöhlmann ML, Dournes C, Uribe-Marino A, Santarelli S, Labermaier C, Hafner K, Mao T, Breitsamer M, Theodoropoulou M, Namendorf C, Uhr M, Paez-Pereda M, Winter G, Hausch F, Chen A, Tschöp MH, Rein T, Gassen NC, Schmidt MV. Balsevich G, et al. Among authors: hausl as. Nat Commun. 2017 Nov 23;8(1):1725. doi: 10.1038/s41467-017-01783-y. Nat Commun. 2017. PMID: 29170369 Free PMC article.
The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice.
Häusl AS, Brix LM, Hartmann J, Pöhlmann ML, Lopez JP, Menegaz D, Brivio E, Engelhardt C, Roeh S, Bajaj T, Rudolph L, Stoffel R, Hafner K, Goss HM, Reul JMHM, Deussing JM, Eder M, Ressler KJ, Gassen NC, Chen A, Schmidt MV. Häusl AS, et al. Mol Psychiatry. 2021 Jul;26(7):3060-3076. doi: 10.1038/s41380-021-01044-x. Epub 2021 Mar 1. Mol Psychiatry. 2021. PMID: 33649453 Free PMC article.
FKBP51 in the Oval Bed Nucleus of the Stria Terminalis Regulates Anxiety-Like Behavior.
Engelhardt C, Tang F, Elkhateib R, Bordes J, Brix LM, van Doeselaar L, Häusl AS, Pöhlmann ML, Schraut K, Yang H, Chen A, Deussing JM, Schmidt MV. Engelhardt C, et al. Among authors: hausl as. eNeuro. 2021 Dec 17;8(6):ENEURO.0425-21.2021. doi: 10.1523/ENEURO.0425-21.2021. Print 2021 Nov-Dec. eNeuro. 2021. PMID: 34872938 Free PMC article.
The co-chaperone FKBP51 modulates HPA axis activity and age-related maladaptation of the stress system in pituitary proopiomelanocortin cells.
Brix LM, Häusl AS, Toksöz I, Bordes J, van Doeselaar L, Engelhardt C, Narayan S, Springer M, Sterlemann V, Deussing JM, Chen A, Schmidt MV. Brix LM, et al. Among authors: hausl as. Psychoneuroendocrinology. 2022 Apr;138:105670. doi: 10.1016/j.psyneuen.2022.105670. Epub 2022 Jan 19. Psychoneuroendocrinology. 2022. PMID: 35091292 Free article.
15 results