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Targeting IL-6 trans-signalling by sgp130Fc attenuates severity in SARS-CoV-2 -infected mice and reduces endotheliopathy.
Rodríguez-Hernández MÁ, Baena-Bustos M, Carneros D, Zurita-Palomo C, Muñoz-Pinillos P, Millán J, Padillo FJ, Smerdou C, von Kobbe C, Rose-John S, Bustos M. Rodríguez-Hernández MÁ, et al. Among authors: rose john s. EBioMedicine. 2024 May;103:105132. doi: 10.1016/j.ebiom.2024.105132. Epub 2024 Apr 26. EBioMedicine. 2024. PMID: 38677182 Free PMC article.
An epithelial gene signature of trans-IL-6 signaling defines a subgroup of type 2-low asthma.
El-Husseini ZW, Khalenkow D, Lan A, van der Molen T, Brightling C, Papi A, Rabe KF, Siddiqui S, Singh D, Kraft M, Beghe B, van den Berge M, van Gosliga D, Nawijn MC, Rose-John S, Koppelman GH, Gosens R. El-Husseini ZW, et al. Among authors: rose john s. Respir Res. 2023 Dec 7;24(1):308. doi: 10.1186/s12931-023-02617-w. Respir Res. 2023. PMID: 38062491 Free PMC article.
A maternal high-fat diet predisposes to infant lung disease via increased neutrophil-mediated IL-6 trans-signaling.
Curren B, Ahmed T, Rashid RB, Sebina I, Al Amin Sikder M, Howard DR, Alorro M, Ullah MA, Bissell A, Rahman MM, Pearen MA, Ramm GA, Varelias A, Rose-John S, MacDonald KPA, Hoelzle R, Ó Cuív P, Spann KM, Dennis PG, Phipps S. Curren B, et al. Among authors: rose john s. Cell Rep. 2024 Nov 26;43(11):114974. doi: 10.1016/j.celrep.2024.114974. Epub 2024 Nov 12. Cell Rep. 2024. PMID: 39535919 Free article.
Cell-autonomous IL6ST activation suppresses prostate cancer development via STAT3/ARF/p53-driven senescence and confers an immune-active tumor microenvironment.
Sternberg C, Raigel M, Limberger T, Trachtová K, Schlederer M, Lindner D, Kodajova P, Yang J, Ziegler R, Kalla J, Stoiber S, Dey S, Zwolanek D, Neubauer HA, Oberhuber M, Redmer T, Hejret V, Tichy B, Tomberger M, Harbusch NS, Pencik J, Tangermann S, Bystry V, Persson JL, Egger G, Pospisilova S, Eferl R, Wolf P, Sternberg F, Högler S, Lagger S, Rose-John S, Kenner L. Sternberg C, et al. Among authors: rose john s. Mol Cancer. 2024 Oct 31;23(1):245. doi: 10.1186/s12943-024-02114-8. Mol Cancer. 2024. PMID: 39482716 Free PMC article.
612 results