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Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance.
Thatikonda V, Lyu H, Jurado S, Kostyrko K, Bristow CA, Albrecht C, Alpar D, Arnhof H, Bergner O, Bosch K, Feng N, Gao S, Gerlach D, Gmachl M, Hinkel M, Lieb S, Jeschko A, Machado AA, Madensky T, Marszalek ED, Mahendra M, Melo-Zainzinger G, Molkentine JM, Jaeger PA, Peng DH, Schenk RL, Sorokin A, Strauss S, Trapani F, Kopetz S, Vellano CP, Petronczki M, Kraut N, Heffernan TP, Marszalek JR, Pearson M, Waizenegger IC, Hofmann MH. Thatikonda V, et al. Among authors: molkentine jm. Nat Cancer. 2024 Sep;5(9):1352-1370. doi: 10.1038/s43018-024-00800-6. Epub 2024 Aug 5. Nat Cancer. 2024. PMID: 39103541 Free PMC article.
Th2 Cells Are Associated with Tumor Recurrence Following Radiation.
Abdelhakiem MK, Bao R, Pifer PM, Molkentine D, Molkentine J, Hefner A, Beadle B, Heymach JV, Luke JJ, Ferris RL, Pickering CR, Wang JH, Patel RB, Skinner HD. Abdelhakiem MK, et al. Among authors: molkentine j. Cancers (Basel). 2024 Apr 20;16(8):1586. doi: 10.3390/cancers16081586. Cancers (Basel). 2024. PMID: 38672668 Free PMC article.
FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner.
Pifer PM, Yang L, Kumar M, Xie T, Frederick M, Hefner A, Beadle B, Molkentine D, Molkentine J, Dhawan A, Abdelhakiem M, Osman AA, Leibowitz BJ, Myers JN, Pickering CR, Sandulache VC, Heymach J, Skinner HD. Pifer PM, et al. Among authors: molkentine j. Clin Cancer Res. 2024 Jan 5;30(1):187-197. doi: 10.1158/1078-0432.CCR-23-0964. Clin Cancer Res. 2024. PMID: 37819945 Free PMC article.
Stromal HIF2 Regulates Immune Suppression in the Pancreatic Cancer Microenvironment.
Garcia Garcia CJ, Huang Y, Fuentes NR, Turner MC, Monberg ME, Lin D, Nguyen ND, Fujimoto TN, Zhao J, Lee JJ, Bernard V, Yu M, Delahoussaye AM, Jimenez Sacarello I, Caggiano EG, Phan JL, Deorukhkar A, Molkentine JM, Saur D, Maitra A, Taniguchi CM. Garcia Garcia CJ, et al. Among authors: molkentine jm. Gastroenterology. 2022 Jun;162(7):2018-2031. doi: 10.1053/j.gastro.2022.02.024. Epub 2022 Feb 22. Gastroenterology. 2022. PMID: 35216965 Free PMC article.
p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade.
Molkentine DP, Molkentine JM, Bridges KA, Valdecanas DR, Dhawan A, Bahri R, Hefner AJ, Kumar M, Yang L, Abdelhakiem M, Pifer PM, Sandulache V, Sheth A, Beadle BM, Thames HD, Mason KA, Pickering CR, Meyn RE, Skinner HD. Molkentine DP, et al. Among authors: molkentine jm. Cancer Res. 2022 Mar 1;82(5):916-928. doi: 10.1158/0008-5472.CAN-21-2101. Cancer Res. 2022. PMID: 34965932 Free PMC article.
Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function.
Kumar M, Molkentine D, Molkentine J, Bridges K, Xie T, Yang L, Hefner A, Gao M, Bahri R, Dhawan A, Frederick MJ, Seth S, Abdelhakiem M, Beadle BM, Johnson F, Wang J, Shen L, Heffernan T, Sheth A, Ferris RL, Myers JN, Pickering CR, Skinner HD. Kumar M, et al. Among authors: molkentine j. Nat Commun. 2021 Nov 3;12(1):6340. doi: 10.1038/s41467-021-26570-8. Nat Commun. 2021. PMID: 34732714 Free PMC article.
Mitochondrial fusion exploits a therapeutic vulnerability of pancreatic cancer.
Yu M, Nguyen ND, Huang Y, Lin D, Fujimoto TN, Molkentine JM, Deorukhkar A, Kang Y, San Lucas FA, Fernandes CJ, Koay EJ, Gupta S, Ying H, Koong AC, Herman JM, Fleming JB, Maitra A, Taniguchi CM. Yu M, et al. Among authors: molkentine jm. JCI Insight. 2019 Jul 23;5(16):e126915. doi: 10.1172/jci.insight.126915. JCI Insight. 2019. PMID: 31335325 Free PMC article.
23 results