Locher KP - Search Results

1

Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB.

Lampson BL, Ramίrez AS, Baro M, He L, Hegde M, Koduri V, Pfaff JL, Hanna RE, Kowal J, Shirole NH, He Y, Doench JG, Contessa JN, Locher KP, Kaelin WG Jr. Lampson BL, et al. Among authors: locher kp. Cell. 2024 Apr 25;187(9):2209-2223.e16. doi: 10.1016/j.cell.2024.03.022. Cell. 2024. PMID: 38670073 Free article.

2

Structure of the multidrug ABC transporter Sav1866 from Staphylococcus aureus in complex with AMP-PNP.

Dawson RJ, Locher KP. Dawson RJ, et al. Among authors: locher kp. FEBS Lett. 2007 Mar 6;581(5):935-8. doi: 10.1016/j.febslet.2007.01.073. Epub 2007 Feb 7. FEBS Lett. 2007. PMID: 17303126 Free article.

3

Crystal structure of the Acidaminococcus fermentans 2-hydroxyglutaryl-CoA dehydratase component A.

Locher KP, Hans M, Yeh AP, Schmid B, Buckel W, Rees DC. Locher KP, et al. J Mol Biol. 2001 Mar 16;307(1):297-308. doi: 10.1006/jmbi.2000.4496. J Mol Biol. 2001. PMID: 11243821

4

X-ray structure of a bacterial oligosaccharyltransferase.

Lizak C, Gerber S, Numao S, Aebi M, Locher KP. Lizak C, et al. Among authors: locher kp. Nature. 2011 Jun 15;474(7351):350-5. doi: 10.1038/nature10151. Nature. 2011. PMID: 21677752

5

Structure of the human multidrug transporter ABCG2.

Taylor NMI, Manolaridis I, Jackson SM, Kowal J, Stahlberg H, Locher KP. Taylor NMI, et al. Among authors: locher kp. Nature. 2017 Jun 22;546(7659):504-509. doi: 10.1038/nature22345. Epub 2017 May 29. Nature. 2017. PMID: 28554189

6

Molecular basis of lipid-linked oligosaccharide recognition and processing by bacterial oligosaccharyltransferase.

Napiórkowska M, Boilevin J, Sovdat T, Darbre T, Reymond JL, Aebi M, Locher KP. Napiórkowska M, et al. Among authors: locher kp. Nat Struct Mol Biol. 2017 Dec;24(12):1100-1106. doi: 10.1038/nsmb.3491. Epub 2017 Oct 23. Nat Struct Mol Biol. 2017. PMID: 29058712

7

Structure of the yeast oligosaccharyltransferase complex gives insight into eukaryotic N-glycosylation.

Wild R, Kowal J, Eyring J, Ngwa EM, Aebi M, Locher KP. Wild R, et al. Among authors: locher kp. Science. 2018 Feb 2;359(6375):545-550. doi: 10.1126/science.aar5140. Epub 2018 Jan 4. Science. 2018. PMID: 29301962

8

Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1.

Alam A, Küng R, Kowal J, McLeod RA, Tremp N, Broude EV, Roninson IB, Stahlberg H, Locher KP. Alam A, et al. Among authors: locher kp. Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E1973-E1982. doi: 10.1073/pnas.1717044115. Epub 2018 Feb 13. Proc Natl Acad Sci U S A. 2018. PMID: 29440498 Free PMC article.

9

Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states.

Manolaridis I, Jackson SM, Taylor NMI, Kowal J, Stahlberg H, Locher KP. Manolaridis I, et al. Among authors: locher kp. Nature. 2018 Nov;563(7731):426-430. doi: 10.1038/s41586-018-0680-3. Epub 2018 Nov 7. Nature. 2018. PMID: 30405239 Free PMC article.

10

Structural insight into substrate and inhibitor discrimination by human P-glycoprotein.

Alam A, Kowal J, Broude E, Roninson I, Locher KP. Alam A, et al. Among authors: locher kp. Science. 2019 Feb 15;363(6428):753-756. doi: 10.1126/science.aav7102. Science. 2019. PMID: 30765569 Free PMC article.

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