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Up-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity.
Zhang T, Yu W, Cheng X, Yeung J, Ahumada V, Norris PC, Pearson MJ, Yang X, van Deursen W, Halcovich C, Nassar A, Vesely MD, Zhang Y, Zhang JP, Ji L, Flies DB, Liu L, Langermann S, LaRochelle WJ, Humphrey R, Zhao D, Zhang Q, Zhang J, Gu R, Schalper KA, Sanmamed MF, Chen L. Zhang T, et al. Among authors: langermann s. Sci Immunol. 2024 Apr 26;9(94):eadh2334. doi: 10.1126/sciimmunol.adh2334. Epub 2024 Apr 26. Sci Immunol. 2024. PMID: 38669316
Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy.
Wang J, Sun J, Liu LN, Flies DB, Nie X, Toki M, Zhang J, Song C, Zarr M, Zhou X, Han X, Archer KA, O'Neill T, Herbst RS, Boto AN, Sanmamed MF, Langermann S, Rimm DL, Chen L. Wang J, et al. Among authors: langermann s. Nat Med. 2019 Apr;25(4):656-666. doi: 10.1038/s41591-019-0374-x. Epub 2019 Mar 4. Nat Med. 2019. PMID: 30833750 Free PMC article.
The FLRT3-UNC5B checkpoint pathway inhibits T cell-based cancer immunotherapies.
Prajapati K, Yan C, Yang Q, Arbitman S, Fitzgerald DP, Sharee S, Shaik J, Bosiacki J, Myers K, Paucarmayta A, Johnson DM, O'Neill T, Kundu S, Cusumano Z, Langermann S, Langenau DM, Patel S, Flies DB. Prajapati K, et al. Among authors: langermann s. Sci Adv. 2024 Mar;10(9):eadj4698. doi: 10.1126/sciadv.adj4698. Epub 2024 Mar 1. Sci Adv. 2024. PMID: 38427724 Free PMC article.
Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction.
Ramos MIP, Tian L, de Ruiter EJ, Song C, Paucarmayta A, Singh A, Elshof E, Vijver SV, Shaik J, Bosiacki J, Cusumano Z, Jensen C, Willumsen N, Karsdal MA, Liu L, Langermann S, Willems S, Flies D, Meyaard L. Ramos MIP, et al. Among authors: langermann s. Elife. 2021 Jun 14;10:e62927. doi: 10.7554/eLife.62927. Elife. 2021. PMID: 34121658 Free PMC article.
Quantitative, Spatially Defined Expression of Leukocyte-associated Immunoglobulin-like Receptor in Non-small Cell Lung Cancer.
Aung TN, Gavrielatou N, Vathiotis IA, Fernandez AI, Shafi S, Yaghoobi V, Burela S, MacNeil T, Ahmed FS, Myint H, Flies DB, Langermann S, Rimm DL. Aung TN, et al. Among authors: langermann s. Cancer Res Commun. 2023 Mar 21;3(3):471-482. doi: 10.1158/2767-9764.CRC-22-0334. eCollection 2023 Mar. Cancer Res Commun. 2023. PMID: 36960400 Free PMC article.
53 results