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Up-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity.
Zhang T, Yu W, Cheng X, Yeung J, Ahumada V, Norris PC, Pearson MJ, Yang X, van Deursen W, Halcovich C, Nassar A, Vesely MD, Zhang Y, Zhang JP, Ji L, Flies DB, Liu L, Langermann S, LaRochelle WJ, Humphrey R, Zhao D, Zhang Q, Zhang J, Gu R, Schalper KA, Sanmamed MF, Chen L. Zhang T, et al. Among authors: ji l. Sci Immunol. 2024 Apr 26;9(94):eadh2334. doi: 10.1126/sciimmunol.adh2334. Epub 2024 Apr 26. Sci Immunol. 2024. PMID: 38669316
Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3.
Wang J, Sanmamed MF, Datar I, Su TT, Ji L, Sun J, Chen L, Chen Y, Zhu G, Yin W, Zheng L, Zhou T, Badri T, Yao S, Zhu S, Boto A, Sznol M, Melero I, Vignali DAA, Schalper K, Chen L. Wang J, et al. Among authors: ji l. Cell. 2019 Jan 10;176(1-2):334-347.e12. doi: 10.1016/j.cell.2018.11.010. Epub 2018 Dec 20. Cell. 2019. PMID: 30580966 Free PMC article.
A Burned-Out CD8+ T-cell Subset Expands in the Tumor Microenvironment and Curbs Cancer Immunotherapy.
Sanmamed MF, Nie X, Desai SS, Villaroel-Espindola F, Badri T, Zhao D, Kim AW, Ji L, Zhang T, Quinlan E, Cheng X, Han X, Vesely MD, Nassar AF, Sun J, Zhang Y, Kim TK, Wang J, Melero I, Herbst RS, Schalper KA, Chen L. Sanmamed MF, et al. Among authors: ji l. Cancer Discov. 2021 Jul;11(7):1700-1715. doi: 10.1158/2159-8290.CD-20-0962. Epub 2021 Mar 3. Cancer Discov. 2021. PMID: 33658301 Free PMC article.
The CD8α-PILRα interaction maintains CD8+ T cell quiescence.
Zheng L, Han X, Yao S, Zhu Y, Klement J, Wu S, Ji L, Zhu G, Cheng X, Tobiasova Z, Yu W, Huang B, Vesely MD, Wang J, Zhang J, Quinlan E, Chen L. Zheng L, et al. Among authors: ji l. Science. 2022 May 27;376(6596):996-1001. doi: 10.1126/science.aaz8658. Epub 2022 May 26. Science. 2022. PMID: 35617401
Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age.
Jacoby JJ, Kalinowski A, Liu MG, Zhang SS, Gao Q, Chai GX, Ji L, Iwamoto Y, Li E, Schneider M, Russell KS, Fu XY. Jacoby JJ, et al. Among authors: ji l. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12929-34. doi: 10.1073/pnas.2134694100. Epub 2003 Oct 17. Proc Natl Acad Sci U S A. 2003. PMID: 14566054 Free PMC article.
Altered 3D genome reorganization mediates precocious myeloid differentiation of aged hematopoietic stem cells in inflammation.
Cui X, Dong Y, Zhan Q, Huang Y, Zhu Q, Zhang Z, Yang G, Wang L, Shen S, Zhao J, Lin Z, Sun J, Su Z, Xiao Y, Zhang C, Liang Y, Shen L, Ji L, Zhang X, Yin J, Wang H, Chen Z, Ju Z, Jiang C, Le R, Gao S. Cui X, et al. Among authors: ji l. Sci China Life Sci. 2024 Dec 27. doi: 10.1007/s11427-024-2754-9. Online ahead of print. Sci China Life Sci. 2024. PMID: 39754007
5,411 results