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Page 1
PGC-1α drives small cell neuroendocrine cancer progression towards an ASCL1-expressing subtype with increased mitochondrial capacity.
Varuzhanyan G, Chen CC, Freeland J, He T, Tran W, Song K, Wang L, Cheng D, Xu S, Dibernardo GA, Esedebe FN, Bhatia V, Han M, Abt ER, Park JW, Memarzadeh S, Shackelford D, Lee JK, Graeber T, Shirihai O, Witte O. Varuzhanyan G, et al. Among authors: graeber t. bioRxiv [Preprint]. 2024 Jul 25:2024.04.09.588489. doi: 10.1101/2024.04.09.588489. bioRxiv. 2024. Update in: Proc Natl Acad Sci U S A. 2024 Dec 3;121(49):e2416882121. doi: 10.1073/pnas.2416882121 PMID: 38645232 Free PMC article. Updated. Preprint.
MITF regulates IDH1 and NNT and drives a transcriptional program protecting cutaneous melanoma from reactive oxygen species.
Roider E, Lakatos AIT, McConnell AM, Wang P, Mueller A, Kawakami A, Tsoi J, Szabolcs BL, Ascsillán AA, Suita Y, Igras V, Lo JA, Hsiao JJ, Lapides R, Pál DMP, Lengyel AS, Navarini A, Okazaki A, Iliopoulos O, Németh I, Graeber TG, Zon L, Giese RW, Kemeny LV, Fisher DE. Roider E, et al. Among authors: graeber tg. bioRxiv [Preprint]. 2023 Nov 14:2023.11.10.564582. doi: 10.1101/2023.11.10.564582. bioRxiv. 2023. Update in: Sci Rep. 2024 Sep 14;14(1):21527. doi: 10.1038/s41598-024-72031-9 PMID: 38014031 Free PMC article. Updated. Preprint.
PGC-1α drives small cell neuroendocrine cancer progression toward an ASCL1-expressing subtype with increased mitochondrial capacity.
Varuzhanyan G, Chen CC, Freeland J, He T, Tran W, Song K, Wang L, Cheng D, Xu S, Dibernardo GA, Esedebe FN, Bhatia V, Han M, Abt ER, Park JW, Memarzadeh S, Shackelford DB, Lee JK, Graeber TG, Shirihai OS, Witte ON. Varuzhanyan G, et al. Among authors: graeber tg. Proc Natl Acad Sci U S A. 2024 Dec 3;121(49):e2416882121. doi: 10.1073/pnas.2416882121. Epub 2024 Nov 26. Proc Natl Acad Sci U S A. 2024. PMID: 39589879 Free PMC article.
Integrated molecular and functional characterization of the intrinsic apoptotic machinery identifies therapeutic vulnerabilities in glioma.
Fernandez EG, Mai WX, Song K, Bayley NA, Kim J, Zhu H, Pioso M, Young P, Andrasz CL, Cadet D, Liau LM, Li G, Yong WH, Rodriguez FJ, Dixon SJ, Souers AJ, Li JJ, Graeber TG, Cloughesy TF, Nathanson DA. Fernandez EG, et al. Among authors: graeber tg. Nat Commun. 2024 Nov 21;15(1):10089. doi: 10.1038/s41467-024-54138-9. Nat Commun. 2024. PMID: 39572533 Free PMC article.
A humanized monoclonal antibody targeting an ectonucleotidase rescues cardiac metabolism and heart function after myocardial infarction.
Li S, Tao B, Wan J, Montecino-Rodriguez E, Wang P, Ma F, Sun B, Gu Y, Ramadoss S, Su L, Sun Q, Hoeve JT, Stiles L, Collins J, van Dam RM, Tamboline M, Taschereau R, Shirihai O, Kitchen DB, Pellegrini M, Graeber T, Dorshkind K, Xu S, Deb A. Li S, et al. Among authors: graeber t. Cell Rep Med. 2024 Nov 19;5(11):101795. doi: 10.1016/j.xcrm.2024.101795. Epub 2024 Oct 24. Cell Rep Med. 2024. PMID: 39454569 Free PMC article.
MITF regulates IDH1, NNT, and a transcriptional program protecting melanoma from reactive oxygen species.
Roider E, Lakatos AIT, McConnell AM, Wang P, Mueller A, Kawakami A, Tsoi J, Szabolcs BL, Ascsillán AA, Suita Y, Igras V, Lo JA, Hsiao JJ, Lapides R, Pál DMP, Lengyel AS, Navarini A, Okazaki A, Iliopoulos O, Németh I, Graeber TG, Zon L, Giese RW, Kemeny LV, Fisher DE. Roider E, et al. Among authors: graeber tg. Sci Rep. 2024 Sep 14;14(1):21527. doi: 10.1038/s41598-024-72031-9. Sci Rep. 2024. PMID: 39277608 Free PMC article.
Targeting Asparagine Metabolism in Well-Differentiated/Dedifferentiated Liposarcoma.
Klingbeil KD, Wilde BR, Graham DS, Lofftus S, McCaw T, Matulionis N, Dry SM, Crompton JG, Eilber FC, Graeber TG, Shackelford DB, Christofk HR, Kadera BE. Klingbeil KD, et al. Among authors: graeber tg. Cancers (Basel). 2024 Aug 30;16(17):3031. doi: 10.3390/cancers16173031. Cancers (Basel). 2024. PMID: 39272889 Free PMC article.
Genetic Screen in a Preclinical Model of Sarcoma Development Defines Drivers and Therapeutic Vulnerabilities.
Freeland J, Muñoz M, O'Donnell E 3rd, Langerman J, Darrow M, Bergonio J, Suarez-Navarro J, Thorpe S, Canter R, Randall RL, Plath K, Carraway KL 3rd, Witte ON, Graeber TG, Carr-Ascher JR. Freeland J, et al. Among authors: graeber tg. Clin Cancer Res. 2024 Nov 1;30(21):4957-4973. doi: 10.1158/1078-0432.CCR-24-1238. Clin Cancer Res. 2024. PMID: 39177582
159 results