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Hydroxymethylglutaryl-CoA reductase activity is essential for mitochondrial β-oxidation of fatty acids to prevent lethal accumulation of long-chain acylcarnitines in the mouse liver.
Liepinsh E, Zvejniece L, Clemensson L, Ozola M, Vavers E, Cirule H, Korzh S, Skuja S, Groma V, Briviba M, Grinberga S, Liu W, Olszewski P, Gentreau M, Fredriksson R, Dambrova M, Schiöth HB. Liepinsh E, et al. Among authors: schioth hb. Br J Pharmacol. 2024 Aug;181(16):2750-2773. doi: 10.1111/bph.16363. Epub 2024 Apr 19. Br J Pharmacol. 2024. PMID: 38641905
Conceptual foundations of acetylcarnitine supplementation in neuropsychiatric long COVID syndrome: a narrative review.
Helbing DL, Dommaschk EM, Danyeli LV, Liepinsh E, Refisch A, Sen ZD, Zvejniece L, Rocktäschel T, Stabenow LK, Schiöth HB, Walter M, Dambrova M, Besteher B. Helbing DL, et al. Among authors: schioth hb. Eur Arch Psychiatry Clin Neurosci. 2024 Dec;274(8):1829-1845. doi: 10.1007/s00406-023-01734-3. Epub 2024 Jan 3. Eur Arch Psychiatry Clin Neurosci. 2024. PMID: 38172332 Free PMC article. Review.
Carbonic anhydrase IX inhibition as a path to treat neuroblastoma.
Petrosiute A, Zakšauskas A, Lučiūnaitė A, Petrauskas V, Baranauskienė L, Kvietkauskaitė A, Ščerbavičienė A, Tamošiūnaitė M, Musvicaitė J, Jankūnaitė A, Žvinys G, Stančaitis L, Čapkauskaitė E, Mickevičiūtė A, Juozapaitienė V, Dudutienė V, Zubrienė A, Grincevičienė Š, Bukelskienė V, Schiöth HB, Matulienė J, Matulis D. Petrosiute A, et al. Among authors: schioth hb. Br J Pharmacol. 2025 Jan 7. doi: 10.1111/bph.17429. Online ahead of print. Br J Pharmacol. 2025. PMID: 39776083
Targeted anticancer pre-vinylsulfone covalent inhibitors of carbonic anhydrase IX.
Vaškevičius A, Baronas D, Leitans J, Kvietkauskaitė A, Rukšėnaitė A, Manakova E, Toleikis Z, Kaupinis A, Kazaks A, Gedgaudas M, Mickevičiūtė A, Juozapaitienė V, Schiöth HB, Jaudzems K, Valius M, Tars K, Gražulis S, Meyer-Almes FJ, Matulienė J, Zubrienė A, Dudutienė V, Matulis D. Vaškevičius A, et al. Among authors: schioth hb. Elife. 2024 Dec 17;13:RP101401. doi: 10.7554/eLife.101401. Elife. 2024. PMID: 39688904 Free PMC article.
Increased ROS levels, antioxidant defense disturbances and bioenergetic disruption induced by thiosulfate administration in the brain of neonatal rats.
Glänzel NM, da Rosa-Junior NT, Signori MF, de Andrade Silveira J, Pinheiro CV, Marcuzzo MB, Campos-Carraro C, da Rosa Araujo AS, Schiöth HB, Wajner M, Leipnitz G. Glänzel NM, et al. Among authors: schioth hb. Metab Brain Dis. 2024 Dec 20;40(1):73. doi: 10.1007/s11011-024-01510-9. Metab Brain Dis. 2024. PMID: 39704910
609 results