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14 results

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Page 1
Safety and efficacy of losmapimod in facioscapulohumeral muscular dystrophy (ReDUX4): a randomised, double-blind, placebo-controlled phase 2b trial.
Tawil R, Wagner KR, Hamel JI, Leung DG, Statland JM, Wang LH, Genge A, Sacconi S, Lochmüller H, Reyes-Leiva D, Diaz-Manera J, Alonso-Perez J, Muelas N, Vilchez JJ, Pestronk A, Gibson S, Goyal NA, Hayward LJ, Johnson N, LoRusso S, Freimer M, Shieh PB, Subramony SH, van Engelen B, Kools J, Leinhard OD, Widholm P, Morabito C, Moxham CM, Cadavid D, Mellion ML, Odueyungbo A, Tracewell WG, Accorsi A, Ronco L, Gould RJ, Shoskes J, Rojas LA, Jiang JG. Tawil R, et al. Among authors: mellion ml. Lancet Neurol. 2024 May;23(5):477-486. doi: 10.1016/S1474-4422(24)00073-5. Lancet Neurol. 2024. PMID: 38631764 Clinical Trial.
An open-label pilot study of losmapimod to evaluate the safety, tolerability, and changes in biomarker and clinical outcome assessments in participants with facioscapulohumeral muscular dystrophy type 1.
Kools J, Voermans N, Jiang JG, Mitelman O, Mellion ML, Ramana V, van Engelen BGM. Kools J, et al. Among authors: mellion ml. J Neurol Sci. 2024 Jul 15;462:123096. doi: 10.1016/j.jns.2024.123096. Epub 2024 Jun 15. J Neurol Sci. 2024. PMID: 38959779 Free article. Clinical Trial.
Quantitative Muscle Analysis in FSHD Using Whole-Body Fat-Referenced MRI: Composite Scores for Longitudinal and Cross-sectional Analysis.
Mellion ML, Widholm P, Karlsson M, Ahlgren A, Tawil R, Wagner KR, Statland JM, Wang L, Shieh PB, van Engelen BGM, Kools J, Ronco L, Odueyungbo A, Jiang J, Han JJ, Hatch M, Towles J, Leinhard OD, Cadavid D. Mellion ML, et al. Neurology. 2022 Aug 30;99(9):e877-e889. doi: 10.1212/WNL.0000000000200757. Epub 2022 Jun 24. Neurology. 2022. PMID: 35750498
Quantitative muscle analysis in facioscapulohumeral muscular dystrophy using whole-body fat-referenced MRI: Protocol development, multicenter feasibility, and repeatability.
Widholm P, Ahlgren A, Karlsson M, Romu T, Tawil R, Wagner KR, Statland JM, Wang LH, Shieh PB, van Engelen BGM, Cadavid D, Ronco L, Odueyungbo AO, Jiang JG, Mellion ML, Dahlqvist Leinhard O. Widholm P, et al. Among authors: mellion ml. Muscle Nerve. 2022 Aug;66(2):183-192. doi: 10.1002/mus.27638. Epub 2022 Jun 11. Muscle Nerve. 2022. PMID: 35585766
Phase 1 clinical trial of losmapimod in facioscapulohumeral dystrophy: Safety, tolerability, pharmacokinetics, and target engagement.
Mellion ML, Ronco L, Berends CL, Pagan L, Brooks S, van Esdonk MJ, van Brummelen EMJ, Odueyungbo A, Thompson LA, Hage M, Badrising UA, Raines S, Tracewell WG, van Engelen B, Cadavid D, Groeneveld GJ. Mellion ML, et al. Br J Clin Pharmacol. 2021 Dec;87(12):4658-4669. doi: 10.1111/bcp.14884. Epub 2021 May 14. Br J Clin Pharmacol. 2021. PMID: 33931884 Free article. Clinical Trial.
Small-fiber degeneration in alcohol-related peripheral neuropathy.
Mellion ML, Silbermann E, Gilchrist JM, Machan JT, Leggio L, de la Monte S. Mellion ML, et al. Alcohol Clin Exp Res. 2014 Jul;38(7):1965-72. doi: 10.1111/acer.12470. Epub 2014 Jun 24. Alcohol Clin Exp Res. 2014. PMID: 24961481 Free PMC article.
Experimental model of alcohol-related peripheral neuropathy.
Mellion ML, Nguyen V, Tong M, Gilchrist J, De La Monte S. Mellion ML, et al. Muscle Nerve. 2013 Aug;48(2):204-11. doi: 10.1002/mus.23744. Epub 2013 Jun 13. Muscle Nerve. 2013. PMID: 23761140 Free PMC article.
A randomized, double-blind, placebo-controlled phase II study of eculizumab in patients with refractory generalized myasthenia gravis.
Howard JF Jr, Barohn RJ, Cutter GR, Freimer M, Juel VC, Mozaffar T, Mellion ML, Benatar MG, Farrugia ME, Wang JJ, Malhotra SS, Kissel JT; MG Study Group. Howard JF Jr, et al. Among authors: mellion ml. Muscle Nerve. 2013 Jul;48(1):76-84. doi: 10.1002/mus.23839. Epub 2013 Apr 30. Muscle Nerve. 2013. PMID: 23512355 Clinical Trial.
Neuropathic pain.
Mellion ML. Mellion ML. Med Health R I. 2008 Jan;91(1):8-10. Med Health R I. 2008. PMID: 18271339 Review. No abstract available.
14 results