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Five multivariate Duchenne muscular dystrophy progression models bridging six-minute walk distance and MRI relaxometry of leg muscles.
Yoon DY, Daniels MJ, Willcocks RJ, Triplett WT, Morales JF, Walter GA, Rooney WD, Vandenborne K, Kim S; DMD MR Biomarker Steering Committee. Yoon DY, et al. Among authors: kim s. J Pharmacokinet Pharmacodyn. 2024 Dec;51(6):671-683. doi: 10.1007/s10928-024-09910-1. Epub 2024 Apr 12. J Pharmacokinet Pharmacodyn. 2024. PMID: 38609673
Towards regulatory endorsement of drug development tools to promote the application of model-informed drug development in Duchenne muscular dystrophy.
Conrado DJ, Larkindale J, Berg A, Hill M, Burton J, Abrams KR, Abresch RT, Bronson A, Chapman D, Crowther M, Duong T, Gordish-Dressman H, Harnisch L, Henricson E, Kim S, McDonald CM, Schmidt S, Vong C, Wang X, Wong BL, Yong F, Romero K; Duchenne Muscular Dystrophy Regulatory Science Consortium (D-RSC). Conrado DJ, et al. Among authors: kim s. J Pharmacokinet Pharmacodyn. 2019 Oct;46(5):441-455. doi: 10.1007/s10928-019-09642-7. Epub 2019 May 24. J Pharmacokinet Pharmacodyn. 2019. PMID: 31127458
Machine Learning in Drug Discovery and Development Part 1: A Primer.
Talevi A, Morales JF, Hather G, Podichetty JT, Kim S, Bloomingdale PC, Kim S, Burton J, Brown JD, Winterstein AG, Schmidt S, White JK, Conrado DJ. Talevi A, et al. Among authors: kim s. CPT Pharmacometrics Syst Pharmacol. 2020 Mar;9(3):129-142. doi: 10.1002/psp4.12491. Epub 2020 Mar 11. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 31905263 Free PMC article.
Development of a model-based clinical trial simulation platform to optimize the design of clinical trials for Duchenne muscular dystrophy.
Lingineni K, Aggarwal V, Morales JF, Conrado DJ, Corey D, Vong C, Burton J, Larkindale J, Romero K, Schmidt S, Kim S; Cooperative International Neuromuscular Research Group investigators and Duchenne Regulatory Science Consortium members. Lingineni K, et al. Among authors: kim s. CPT Pharmacometrics Syst Pharmacol. 2022 Mar;11(3):318-332. doi: 10.1002/psp4.12753. Epub 2022 Jan 3. CPT Pharmacometrics Syst Pharmacol. 2022. PMID: 34877803 Free PMC article.
Evaluating Genetic Modifiers of Duchenne Muscular Dystrophy Disease Progression Using Modeling and MRI.
Barnard AM, Hammers DW, Triplett WT, Kim S, Forbes SC, Willcocks RJ, Daniels MJ, Senesac CR, Lott DJ, Arpan I, Rooney WD, Wang RT, Nelson SF, Sweeney HL, Vandenborne K, Walter GA. Barnard AM, et al. Among authors: kim s. Neurology. 2022 Nov 22;99(21):e2406-e2416. doi: 10.1212/WNL.0000000000201163. Epub 2022 Sep 2. Neurology. 2022. PMID: 36240102 Free PMC article.
Disease progression joint model predicts time to type 1 diabetes onset: Optimizing future type 1 diabetes prevention studies.
Morales JF, Muse R, Podichetty JT, Burton J, David S, Lang P, Schmidt S, Romero K, O'Doherty I, Martin F, Campbell-Thompson M, Haller MJ, Atkinson MA, Kim S. Morales JF, et al. Among authors: kim s. CPT Pharmacometrics Syst Pharmacol. 2023 Jul;12(7):1016-1028. doi: 10.1002/psp4.12973. Epub 2023 May 3. CPT Pharmacometrics Syst Pharmacol. 2023. PMID: 37186151 Free PMC article.
Multivariate modeling of magnetic resonance biomarkers and clinical outcome measures for Duchenne muscular dystrophy clinical trials.
Kim S, Willcocks RJ, Daniels MJ, Morales JF, Yoon DY, Triplett WT, Barnard AM, Conrado DJ, Aggarwal V, Belfiore-Oshan R, Martinez TN, Walter GA, Rooney WD, Vandenborne K. Kim S, et al. CPT Pharmacometrics Syst Pharmacol. 2023 Oct;12(10):1437-1449. doi: 10.1002/psp4.13021. Epub 2023 Aug 27. CPT Pharmacometrics Syst Pharmacol. 2023. PMID: 37534782 Free PMC article.
Clinical importance of changes in magnetic resonance biomarkers for Duchenne muscular dystrophy.
Willcocks RJ, Barnard AM, Daniels MJ, Forbes SC, Triplett WT, Brandsema JF, Finanger EL, Rooney WD, Kim S, Wang DJ, Lott DJ, Senesac CR, Walter GA, Sweeney HL, Vandenborne K. Willcocks RJ, et al. Among authors: kim s. Ann Clin Transl Neurol. 2024 Jan;11(1):67-78. doi: 10.1002/acn3.51933. Epub 2023 Nov 6. Ann Clin Transl Neurol. 2024. PMID: 37932907 Free PMC article.
Type 1 diabetes prevention clinical trial simulator: Case reports of model-informed drug development tool.
Morales JF, Klose M, Hoffert Y, Podichetty JT, Burton J, Schmidt S, Romero K, O'Doherty I, Martin F, Campbell-Thompson M, Haller MJ, Atkinson MA, Kim S. Morales JF, et al. Among authors: kim s. CPT Pharmacometrics Syst Pharmacol. 2024 Aug;13(8):1309-1316. doi: 10.1002/psp4.13193. Epub 2024 Jul 3. CPT Pharmacometrics Syst Pharmacol. 2024. PMID: 38961520 Free PMC article.
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