Wade-Martins R - Search Results

1

Early deficits in an in vitro striatal microcircuit model carrying the Parkinson's GBA-N370S mutation.

Do QB, Noor H, Marquez-Gomez R, Cramb KML, Ng B, Abbey A, Ibarra-Aizpurua N, Caiazza MC, Sharifi P, Lang C, Beccano-Kelly D, Baleriola J, Bengoa-Vergniory N, Wade-Martins R. Do QB, et al. Among authors: wade martins r. NPJ Parkinsons Dis. 2024 Apr 12;10(1):82. doi: 10.1038/s41531-024-00694-2. NPJ Parkinsons Dis. 2024. PMID: 38609392 Free PMC article.

2

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons.

Fernandes HJ, Hartfield EM, Christian HC, Emmanoulidou E, Zheng Y, Booth H, Bogetofte H, Lang C, Ryan BJ, Sardi SP, Badger J, Vowles J, Evetts S, Tofaris GK, Vekrellis K, Talbot K, Hu MT, James W, Cowley SA, Wade-Martins R. Fernandes HJ, et al. Stem Cell Reports. 2016 Mar 8;6(3):342-56. doi: 10.1016/j.stemcr.2016.01.013. Epub 2016 Feb 18. Stem Cell Reports. 2016. PMID: 26905200 Free PMC article.

3

Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson's disease.

Sandor C, Robertson P, Lang C, Heger A, Booth H, Vowles J, Witty L, Bowden R, Hu M, Cowley SA, Wade-Martins R, Webber C. Sandor C, et al. Hum Mol Genet. 2017 Feb 1;26(3):552-566. doi: 10.1093/hmg/ddw412. Hum Mol Genet. 2017. PMID: 28096185 Free PMC article.

4

Increased 4R tau expression and behavioural changes in a novel MAPT-N296H genomic mouse model of tauopathy.

Wobst HJ, Denk F, Oliver PL, Livieratos A, Taylor TN, Knudsen MH, Bengoa-Vergniory N, Bannerman D, Wade-Martins R. Wobst HJ, et al. Sci Rep. 2017 Feb 24;7:43198. doi: 10.1038/srep43198. Sci Rep. 2017. PMID: 28233851 Free PMC article.

5

Preclinical development of a vaccine against oligomeric alpha-synuclein based on virus-like particles.

Doucet M, El-Turabi A, Zabel F, Hunn BHM, Bengoa-Vergniory N, Cioroch M, Ramm M, Smith AM, Gomes AC, Cabral de Miranda G, Wade-Martins R, Bachmann MF. Doucet M, et al. PLoS One. 2017 Aug 10;12(8):e0181844. doi: 10.1371/journal.pone.0181844. eCollection 2017. PLoS One. 2017. PMID: 28797124 Free PMC article.

6

Alpha-synuclein oligomers: a new hope.

Bengoa-Vergniory N, Roberts RF, Wade-Martins R, Alegre-Abarrategui J. Bengoa-Vergniory N, et al. Acta Neuropathol. 2017 Dec;134(6):819-838. doi: 10.1007/s00401-017-1755-1. Epub 2017 Aug 12. Acta Neuropathol. 2017. PMID: 28803412 Free PMC article. Review.

7

Loss of MicroRNA-7 Regulation Leads to α-Synuclein Accumulation and Dopaminergic Neuronal Loss In Vivo.

McMillan KJ, Murray TK, Bengoa-Vergniory N, Cordero-Llana O, Cooper J, Buckley A, Wade-Martins R, Uney JB, O'Neill MJ, Wong LF, Caldwell MA. McMillan KJ, et al. Mol Ther. 2017 Oct 4;25(10):2404-2414. doi: 10.1016/j.ymthe.2017.08.017. Epub 2017 Aug 31. Mol Ther. 2017. PMID: 28927576 Free PMC article.

8

Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes.

Lang C, Campbell KR, Ryan BJ, Carling P, Attar M, Vowles J, Perestenko OV, Bowden R, Baig F, Kasten M, Hu MT, Cowley SA, Webber C, Wade-Martins R. Lang C, et al. Cell Stem Cell. 2019 Jan 3;24(1):93-106.e6. doi: 10.1016/j.stem.2018.10.023. Epub 2018 Nov 29. Cell Stem Cell. 2019. PMID: 30503143 Free PMC article.

9

Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons.

Zambon F, Cherubini M, Fernandes HJR, Lang C, Ryan BJ, Volpato V, Bengoa-Vergniory N, Vingill S, Attar M, Booth HDE, Haenseler W, Vowles J, Bowden R, Webber C, Cowley SA, Wade-Martins R. Zambon F, et al. Hum Mol Genet. 2019 Jun 15;28(12):2001-2013. doi: 10.1093/hmg/ddz038. Hum Mol Genet. 2019. PMID: 30753527 Free PMC article.

10

Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior.

Hunn BHM, Vingill S, Threlfell S, Alegre-Abarrategui J, Magdelyns M, Deltheil T, Bengoa-Vergniory N, Oliver PL, Cioroch M, Doig NM, Bannerman DM, Cragg SJ, Wade-Martins R. Hunn BHM, et al. Cell Rep. 2019 Oct 22;29(4):920-931.e7. doi: 10.1016/j.celrep.2019.09.029. Cell Rep. 2019. PMID: 31644913 Free PMC article.

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