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DNAJC9 prevents CENP-A mislocalization and chromosomal instability by maintaining the fidelity of histone supply chains.
Balachandra V, Shrestha RL, Hammond CM, Lin S, Hendriks IA, Sethi SC, Chen L, Sevilla S, Caplen NJ, Chari R, Karpova TS, McKinnon K, Todd MA, Koparde V, Cheng KC, Nielsen ML, Groth A, Basrai MA. Balachandra V, et al. Among authors: chen l. EMBO J. 2024 Jun;43(11):2166-2197. doi: 10.1038/s44318-024-00093-6. Epub 2024 Apr 10. EMBO J. 2024. PMID: 38600242 Free PMC article.
Glucocerebrosidase as a therapeutic target for Parkinson's disease.
Chen Y, Sam R, Sharma P, Chen L, Do J, Sidransky E. Chen Y, et al. Among authors: chen l. Expert Opin Ther Targets. 2020 Apr;24(4):287-294. doi: 10.1080/14728222.2020.1733970. Epub 2020 Feb 27. Expert Opin Ther Targets. 2020. PMID: 32106725 Free PMC article. Review.
Multi-Component, Time-Course screening to develop combination cancer therapies based on synergistic toxicity.
Ceribelli M, Tosto FA, Zhang X, Melani CJ, Roschewski M, Beck E, Klumpp-Thomas C, Peer CJ, Wilson KM, Chen L, McKnight C, Michael S, Itkin Z, Shinn P, Figg WD Sr, Wilson WH, Staudt LM, Thomas CJ. Ceribelli M, et al. Among authors: chen l. Proc Natl Acad Sci U S A. 2024 Dec 3;121(49):e2413372121. doi: 10.1073/pnas.2413372121. Epub 2024 Nov 25. Proc Natl Acad Sci U S A. 2024. PMID: 39585996 Free PMC article.
High-throughput and targeted drug screens identify pharmacological candidates against MiT-translocation renal cell carcinoma.
Lang M, Schmidt LS, Wilson KM, Ricketts CJ, Sourbier C, Vocke CD, Wei D, Crooks DR, Yang Y, Gibbs BK, Zhang X, Klumpp-Thomas C, Chen L, Guha R, Ferrer M, McKnight C, Itkin Z, Wangsa D, Wangsa D, James A, Difilippantonio S, Karim B, Morís F, Ried T, Merino MJ, Srinivasan R, Thomas CJ, Linehan WM. Lang M, et al. Among authors: chen l. J Exp Clin Cancer Res. 2023 Apr 25;42(1):99. doi: 10.1186/s13046-023-02667-4. J Exp Clin Cancer Res. 2023. PMID: 37095531 Free PMC article.
High-throughput approaches to uncover synergistic drug combinations in leukemia.
Chory EJ, Wang M, Ceribelli M, Michalowska AM, Golas S, Beck E, Klumpp-Thomas C, Chen L, McKnight C, Itkin Z, Wilson KM, Holland D, Divakaran S, Bradner J, Khan J, Gryder BE, Thomas CJ, Stanton BZ. Chory EJ, et al. Among authors: chen l. SLAS Discov. 2023 Jun;28(4):193-201. doi: 10.1016/j.slasd.2023.04.004. Epub 2023 Apr 29. SLAS Discov. 2023. PMID: 37121274 Free PMC article.
Cognitive and Alzheimer's disease biomarker effects of oral nicotinamide riboside (NR) supplementation in older adults with subjective cognitive decline and mild cognitive impairment.
Wu CY, Kupferschmid AC, Chen L, McManus AJ, Kivisäkk P, Galler JA, Schwab NA, DesRuisseaux LA, Williams VJ, Gerber J, Riley M, Young C, Guzmán-Vélez E, Dodge HH, Tanzi RE, Singer CM, Arnold SE. Wu CY, et al. Among authors: chen l. Alzheimers Dement (N Y). 2025 Jan 15;11(1):e70023. doi: 10.1002/trc2.70023. eCollection 2025 Jan-Mar. Alzheimers Dement (N Y). 2025. PMID: 39817194 Free PMC article.
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