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Page 1
(S)-ML-SA1 Activates Autophagy via TRPML1-TFEB Pathway.
Cunha MR, Do Amaral BS, Takarada JE, Valderrama GV, Batista ANL, Batista JM Jr, Cass QB, Couñago RM, Massirer KB. Cunha MR, et al. Among authors: massirer kb. Chembiochem. 2024 Nov 18;25(22):e202400506. doi: 10.1002/cbic.202400506. Epub 2024 Aug 12. Chembiochem. 2024. PMID: 38923811
UHMK1 is a novel splicing regulatory kinase.
Arfelli VC, Chang YC, Bagnoli JW, Kerbs P, Ciamponi FE, Paz LMDS, Pankivskyi S, de Matha Salone J, Maucuer A, Massirer KB, Enard W, Kuster B, Greif PA, Archangelo LF. Arfelli VC, et al. Among authors: massirer kb. J Biol Chem. 2023 Apr;299(4):103041. doi: 10.1016/j.jbc.2023.103041. Epub 2023 Feb 18. J Biol Chem. 2023. PMID: 36803961 Free PMC article.
Identification of inhibitors for the transmembrane Trypanosoma cruzi eIF2α kinase relevant for parasite proliferation.
Marcelino TP, Fala AM, da Silva MM, Souza-Melo N, Malvezzi AM, Klippel AH, Zoltner M, Padilla-Mejia N, Kosto S, Field MC, Burle-Caldas GA, Teixeira SMR, Couñago RM, Massirer KB, Schenkman S. Marcelino TP, et al. Among authors: massirer kb. J Biol Chem. 2023 Jul;299(7):104857. doi: 10.1016/j.jbc.2023.104857. Epub 2023 May 23. J Biol Chem. 2023. PMID: 37230387 Free PMC article.
Discovery of pyrazolo[3,4-d]pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors.
Takarada JE, Cunha MR, Almeida VM, Vasconcelos SNS, Santiago AS, Godoi PH, Salmazo A, Ramos PZ, Fala AM, de Souza LR, Da Silva IEP, Bengtson MH, Massirer KB, Couñago RM. Takarada JE, et al. Among authors: massirer kb. Bioorg Med Chem. 2024 Jan 15;98:117561. doi: 10.1016/j.bmc.2023.117561. Epub 2023 Dec 20. Bioorg Med Chem. 2024. PMID: 38157838 Free article.
Identification of potential inhibitors of casein kinase 2 alpha of Plasmodium falciparum with potent in vitro activity.
Tomaz KCP, Tavella TA, Borba JVB, Salazar-Alvarez LC, Levandoski JE, Mottin M, Sousa BKP, Moreira-Filho JT, Almeida VM, Clementino LC, Bourgard C, Massirer KB, Couñago RM, Andrade CH, Sunnerhagen P, Bilsland E, Cassiano GC, Costa FTM. Tomaz KCP, et al. Among authors: massirer kb. Antimicrob Agents Chemother. 2023 Nov 15;67(11):e0058923. doi: 10.1128/aac.00589-23. Epub 2023 Oct 11. Antimicrob Agents Chemother. 2023. PMID: 37819090 Free PMC article.
A chemical screen identifies PRMT5 as a therapeutic vulnerability for paclitaxel-resistant triple-negative breast cancer.
Zhang K, Wei J, Zhang S, Fei L, Guo L, Liu X, Ji Y, Chen W, Ciamponi FE, Chen W, Li M, Zhai J, Fu T, Massirer KB, Yu Y, Lupien M, Wei Y, Arrowsmith CH, Wu Q, Tan W. Zhang K, et al. Among authors: massirer kb. Cell Chem Biol. 2024 Nov 21;31(11):1942-1957.e6. doi: 10.1016/j.chembiol.2024.08.003. Epub 2024 Sep 3. Cell Chem Biol. 2024. PMID: 39232499
Leishmania mexicana N-Acetyltransferease 10 Is Important for Polysome Formation and Cell Cycle Progression.
Maran SR, Leite AB, Alves GG, Bonifácio BS, Alves CE, Moreira POL, Panessa GM, Prado HMDA, Klippel AH, Cussiol JR, Massirer KB, Ferreira TR, Sacks D, Barbiéri CL, Silva MSD, Monte-Neto RLD, Silvio Moretti N. Maran SR, et al. Among authors: massirer kb. Mol Microbiol. 2025 Jan;123(1):60-74. doi: 10.1111/mmi.15338. Epub 2025 Jan 4. Mol Microbiol. 2025. PMID: 39755945
46 results