Canal CE - Search Results

1

Synthesis and Structure-Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Long-Acting Serotonin 5-HT₂ Receptor Agonist.

Varty GB, Canal CE, Mueller TA, Hartsel JA, Tyagi R, Avery K, Morgan ME, Reichelt AC, Pathare P, Stang E, Palfreyman MG, Nivorozhkin A. Varty GB, et al. Among authors: canal ce. J Med Chem. 2024 Apr 25;67(8):6144-6188. doi: 10.1021/acs.jmedchem.3c01961. Epub 2024 Apr 9. J Med Chem. 2024. PMID: 38593423

2

The Psychedelic N,N-Dipropyltryptamine Prevents Seizures in a Mouse Model of Fragile X Syndrome via a Mechanism that Appears Independent of Serotonin and Sigma1 Receptors.

Tyagi R, Saraf TS, Canal CE. Tyagi R, et al. Among authors: canal ce. ACS Pharmacol Transl Sci. 2023 Sep 18;6(10):1480-1491. doi: 10.1021/acsptsci.3c00137. eCollection 2023 Oct 13. ACS Pharmacol Transl Sci. 2023. PMID: 37854624 Free PMC article.

3

Altered brain serotonin 5-HT_1A receptor expression and function in juvenile Fmr1 knockout mice.

Saraf TS, Chen Y, Tyagi R, Canal CE. Saraf TS, et al. Among authors: canal ce. Neuropharmacology. 2024 Mar 1;245:109774. doi: 10.1016/j.neuropharm.2023.109774. Epub 2023 Nov 3. Neuropharmacology. 2024. PMID: 37923121

4

Novel 4-substituted-N,N-dimethyltetrahydronaphthalen-2-amines: synthesis, affinity, and in silico docking studies at serotonin 5-HT2-type and histamine H1 G protein-coupled receptors.

Sakhuja R, Kondabolu K, Córdova-Sintjago T, Travers S, Vincek AS, Kim MS, Abboud KA, Fang L, Sun Z, Canal CE, Booth RG. Sakhuja R, et al. Among authors: canal ce. Bioorg Med Chem. 2015 Apr 1;23(7):1588-600. doi: 10.1016/j.bmc.2015.01.060. Epub 2015 Feb 7. Bioorg Med Chem. 2015. PMID: 25703249 Free PMC article.

5

Activity of Mitragyna speciosa ("Kratom") Alkaloids at Serotonin Receptors.

León F, Obeng S, Mottinelli M, Chen Y, King TI, Berthold EC, Kamble SH, Restrepo LF, Patel A, Gamez-Jimenez LR, Lopera-Londoño C, Hiranita T, Sharma A, Hampson AJ, Canal CE, McMahon LR, McCurdy CR. León F, et al. Among authors: canal ce. J Med Chem. 2021 Sep 23;64(18):13510-13523. doi: 10.1021/acs.jmedchem.1c00726. Epub 2021 Sep 1. J Med Chem. 2021. PMID: 34467758 Free PMC article.

6

Synthesis of novel 5-substituted-2-aminotetralin analogs: 5-HT_1A and 5-HT₇ G protein-coupled receptor affinity, 3D-QSAR and molecular modeling.

Perry CK, Casey AB, Felsing DE, Vemula R, Zaka M, Herrington NB, Cui M, Kellogg GE, Canal CE, Booth RG. Perry CK, et al. Among authors: canal ce. Bioorg Med Chem. 2020 Feb 1;28(3):115262. doi: 10.1016/j.bmc.2019.115262. Epub 2019 Dec 12. Bioorg Med Chem. 2020. PMID: 31882369

7

FPT, a 2-Aminotetralin, Is a Potent Serotonin 5-HT_1A, 5-HT_1B, and 5-HT_1D Receptor Agonist That Modulates Cortical Electroencephalogram Activity in Adult Fmr1 Knockout Mice.

Saraf TS, McGlynn RP, Bhatavdekar OM, Booth RG, Canal CE. Saraf TS, et al. Among authors: canal ce. ACS Chem Neurosci. 2022 Dec 21;13(24):3629-3640. doi: 10.1021/acschemneuro.2c00574. Epub 2022 Dec 6. ACS Chem Neurosci. 2022. PMID: 36473166 Free PMC article.

8

The serotonin 5-HT_2C receptor and the non-addictive nature of classic hallucinogens.

Canal CE, Murnane KS. Canal CE, et al. J Psychopharmacol. 2017 Jan;31(1):127-143. doi: 10.1177/0269881116677104. Epub 2016 Nov 15. J Psychopharmacol. 2017. PMID: 27903793 Free PMC article. Review.

9

"Selective" serotonin 5-HT_2A receptor antagonists.

Casey AB, Cui M, Booth RG, Canal CE. Casey AB, et al. Among authors: canal ce. Biochem Pharmacol. 2022 Jun;200:115028. doi: 10.1016/j.bcp.2022.115028. Epub 2022 Apr 4. Biochem Pharmacol. 2022. PMID: 35381208 Free PMC article. Review.

10

The synthetic cathinone psychostimulant α-PPP antagonizes serotonin 5-HT_2A receptors: In vitro and in vivo evidence.

Chen Y, Blough BE, Murnane KS, Canal CE. Chen Y, et al. Among authors: canal ce. Drug Test Anal. 2019 Jul;11(7):990-998. doi: 10.1002/dta.2582. Epub 2019 Apr 22. Drug Test Anal. 2019. PMID: 30845376 Free PMC article.

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