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Neural cells secrete a unique repertoire of proteins.
Schubert D, Herrera F, Cumming R, Read J, Low W, Maher P, Fischer WH. Schubert D, et al. Among authors: maher p. J Neurochem. 2009 Apr;109(2):427-35. doi: 10.1111/j.1471-4159.2009.05968.x. Epub 2009 Feb 7. J Neurochem. 2009. PMID: 19200335 Free PMC article.
Intraneuronal protein aggregation as a trigger for inflammation and neurodegeneration in the aging brain.
Currais A, Fischer W, Maher P, Schubert D. Currais A, et al. Among authors: maher p. FASEB J. 2017 Jan;31(1):5-10. doi: 10.1096/fj.201601184. FASEB J. 2017. PMID: 28049155 Free PMC article. Review.
As most of these diseases are associated with the accumulation of aggregated proteins, it is possible that any therapeutic that reduces intracellular protein aggregation will benefit all.-Currais, A., Fischer, W., Maher, P., Schubert, D. Intraneuronal protein aggreg …
As most of these diseases are associated with the accumulation of aggregated proteins, it is possible that any therapeutic that reduces intr …
The mitochondrial ATP synthase is a shared drug target for aging and dementia.
Goldberg J, Currais A, Prior M, Fischer W, Chiruta C, Ratliff E, Daugherty D, Dargusch R, Finley K, Esparza-Moltó PB, Cuezva JM, Maher P, Petrascheck M, Schubert D. Goldberg J, et al. Among authors: maher p. Aging Cell. 2018 Apr;17(2):e12715. doi: 10.1111/acel.12715. Epub 2018 Jan 7. Aging Cell. 2018. PMID: 29316249 Free PMC article.
Geroneuroprotectors: Effective Geroprotectors for the Brain.
Schubert D, Currais A, Goldberg J, Finley K, Petrascheck M, Maher P. Schubert D, et al. Among authors: maher p. Trends Pharmacol Sci. 2018 Dec;39(12):1004-1007. doi: 10.1016/j.tips.2018.09.008. Epub 2018 Nov 13. Trends Pharmacol Sci. 2018. PMID: 30446211 Free PMC article. Review.
437 results