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Therapeutic administration of a cross-reactive mAb targeting the fusion glycoprotein of Nipah virus protects nonhuman primates.
Zeitlin L, Cross RW, Woolsey C, West BR, Borisevich V, Agans KN, Prasad AN, Deer DJ, Stuart L, McCavitt-Malvido M, Kim DH, Pettitt J, Crowe JE Jr, Whaley KJ, Veesler D, Dimitrov A, Abelson DM, Geisbert TW, Broder CC. Zeitlin L, et al. Among authors: west br. Sci Transl Med. 2024 Apr 3;16(741):eadl2055. doi: 10.1126/scitranslmed.adl2055. Epub 2024 Apr 3. Sci Transl Med. 2024. PMID: 38569014
Broadly neutralizing antibody cocktails targeting Nipah virus and Hendra virus fusion glycoproteins.
Dang HV, Cross RW, Borisevich V, Bornholdt ZA, West BR, Chan YP, Mire CE, Da Silva SC, Dimitrov AS, Yan L, Amaya M, Navaratnarajah CK, Zeitlin L, Geisbert TW, Broder CC, Veesler D. Dang HV, et al. Among authors: west br. Nat Struct Mol Biol. 2021 May;28(5):426-434. doi: 10.1038/s41594-021-00584-8. Epub 2021 Apr 29. Nat Struct Mol Biol. 2021. PMID: 33927387
Cooperativity mediated by rationally selected combinations of human monoclonal antibodies targeting the henipavirus receptor binding protein.
Doyle MP, Kose N, Borisevich V, Binshtein E, Amaya M, Nagel M, Annand EJ, Armstrong E, Bombardi R, Dong J, Schey KL, Broder CC, Zeitlin L, Kuang EA, Bornholdt ZA, West BR, Geisbert TW, Cross RW, Crowe JE Jr. Doyle MP, et al. Among authors: west br. Cell Rep. 2021 Aug 31;36(9):109628. doi: 10.1016/j.celrep.2021.109628. Cell Rep. 2021. PMID: 34469726 Free PMC article.
Structural basis of broad ebolavirus neutralization by a human survivor antibody.
West BR, Wec AZ, Moyer CL, Fusco ML, Ilinykh PA, Huang K, Wirchnianski AS, James RM, Herbert AS, Hui S, Goodwin E, Howell KA, Kailasan S, Aman MJ, Walker LM, Dye JM, Bukreyev A, Chandran K, Saphire EO. West BR, et al. Nat Struct Mol Biol. 2019 Mar;26(3):204-212. doi: 10.1038/s41594-019-0191-4. Epub 2019 Mar 4. Nat Struct Mol Biol. 2019. PMID: 30833785 Free PMC article.
Achieving cross-reactivity with pan-ebolavirus antibodies.
King LB, Milligan JC, West BR, Schendel SL, Ollmann Saphire E. King LB, et al. Among authors: west br. Curr Opin Virol. 2019 Feb;34:140-148. doi: 10.1016/j.coviro.2019.01.003. Epub 2019 Mar 15. Curr Opin Virol. 2019. PMID: 30884329 Free PMC article. Review.
Pan-ebolavirus serology study of healthcare workers in the Mbandaka Health Region, Democratic Republic of the Congo.
Shaffer KCL, Hui S, Bratcher A, King LB, Mutombe R, Kavira N, Kompany JP, Tambu M, Musene K, Mukadi P, Mbala P, Gadoth A, West BR, Ilunga BK, Kaba D, Muyembe-Tanfum JJ, Hoff NA, Rimoin AW, Saphire EO. Shaffer KCL, et al. Among authors: west br. PLoS Negl Trop Dis. 2022 Mar 7;16(3):e0010167. doi: 10.1371/journal.pntd.0010167. eCollection 2022 Mar. PLoS Negl Trop Dis. 2022. PMID: 35255093 Free PMC article.
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