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Covariate modeling in pharmacometrics: General points for consideration.
Sanghavi K, Ribbing J, Rogers JA, Ahmed MA, Karlsson MO, Holford N, Chasseloup E, Ahamadi M, Kowalski KG, Cole S, Kerwash E, Wade JR, Liu C, Wang Y, Trame MN, Zhu H, Wilkins JJ; ISoP Standards & Best Practices Committee. Sanghavi K, et al. Among authors: trame mn. CPT Pharmacometrics Syst Pharmacol. 2024 May;13(5):710-728. doi: 10.1002/psp4.13115. Epub 2024 Apr 2. CPT Pharmacometrics Syst Pharmacol. 2024. PMID: 38566433 Free PMC article. Review.
Perspective on the State of Pharmacometrics and Systems Pharmacology Integration.
Trame MN, Riggs M, Biliouris K, Marathe D, Mettetal J, Post TM, Rizk ML, Visser SAG, Musante CJ. Trame MN, et al. CPT Pharmacometrics Syst Pharmacol. 2018 Oct;7(10):617-620. doi: 10.1002/psp4.12313. Epub 2018 Aug 21. CPT Pharmacometrics Syst Pharmacol. 2018. PMID: 29761892 Free PMC article. Review.
Challenges in Alzheimer's Disease Drug Discovery and Development: The Role of Modeling, Simulation, and Open Data.
Conrado DJ, Duvvuri S, Geerts H, Burton J, Biesdorf C, Ahamadi M, Macha S, Hather G, Francisco Morales J, Podichetty J, Nicholas T, Stephenson D, Trame M, Romero K, Corrigan B; Drug Development Tools in the Alzheimer Disease Continuum (DDT-AD) Working Group. Conrado DJ, et al. Clin Pharmacol Ther. 2020 Apr;107(4):796-805. doi: 10.1002/cpt.1782. Epub 2020 Mar 11. Clin Pharmacol Ther. 2020. PMID: 31955409 Review.
A Semi-Mechanistic Population Pharmacokinetic Model of Nusinersen: An Antisense Oligonucleotide for the Treatment of Spinal Muscular Atrophy.
Biliouris K, Gaitonde P, Yin W, Norris DA, Wang Y, Henry S, Fey R, Nestorov I, Schmidt S, Rogge M, Lesko LJ, Trame MN. Biliouris K, et al. Among authors: trame mn. CPT Pharmacometrics Syst Pharmacol. 2018 Sep;7(9):581-592. doi: 10.1002/psp4.12323. Epub 2018 Aug 16. CPT Pharmacometrics Syst Pharmacol. 2018. PMID: 30043511 Free PMC article.
Is Bioequivalence Established Based on the Reference-Scaled Average Bioequivalence Approach Relevant to Chronic Administration of Phenytoin? Perspectives Based on Population Pharmacokinetic Modeling and Simulations.
Kim H, Fang L, Yu J, Meng Z, Trame MN, Schmidt S, Lesko LJ, Zhao L. Kim H, et al. Among authors: trame mn. J Clin Pharmacol. 2019 Aug;59(8):1061-1069. doi: 10.1002/jcph.1380. Epub 2019 Feb 4. J Clin Pharmacol. 2019. PMID: 30716169 Clinical Trial.
37 results