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Integrated multiomics implicates dysregulation of ECM and cell adhesion pathways as drivers of severe COVID-associated kidney injury.
Anandakrishnan N, Yi Z, Sun Z, Liu T, Haydak J, Eddy S, Jayaraman P, DeFronzo S, Saha A, Sun Q, Yang D, Mendoza A, Mosoyan G, Wen HH, Schaub JA, Fu J, Kehrer T, Menon R, Otto EA, Godfrey B, Suarez-Farinas M, Leffters S, Twumasi A, Meliambro K, Charney AW, García-Sastre A, Campbell KN, Gusella GL, He JC, Miorin L, Nadkarni GN, Wisnivesky J, Li H, Kretzler M, Coca SG, Chan L, Zhang W, Azeloglu EU. Anandakrishnan N, et al. Among authors: kehrer t. medRxiv [Preprint]. 2024 Mar 19:2024.03.18.24304401. doi: 10.1101/2024.03.18.24304401. medRxiv. 2024. PMID: 38562892 Free PMC article. Preprint.
Physiology of cardiomyocyte injury in COVID-19.
Siddiq MM, Chan AT, Miorin L, Yadaw AS, Beaumont KG, Kehrer T, White KM, Cupic A, Tolentino RE, Hu B, Stern AD, Tavassoly I, Hansen J, Martinez P, Dubois N, Schaniel C, Iyengar-Kapuganti R, Kukar N, Giustino G, Sud K, Nirenberg S, Kovatch P, Goldfarb J, Croft L, McLaughlin MA, Argulian E, Lerakis S, Narula J, García-Sastre A, Iyengar R. Siddiq MM, et al. Among authors: kehrer t. medRxiv [Preprint]. 2020 Nov 16:2020.11.10.20229294. doi: 10.1101/2020.11.10.20229294. medRxiv. 2020. Update in: J Virol. 2022 Jan 26;96(2):e0106321. doi: 10.1128/JVI.01063-21 PMID: 33200140 Free PMC article. Updated. Preprint.
The N501Y mutation in SARS-CoV-2 spike leads to morbidity in obese and aged mice and is neutralized by convalescent and post-vaccination human sera.
Rathnasinghe R, Jangra S, Cupic A, Martínez-Romero C, Mulder LCF, Kehrer T, Yildiz S, Choi A, Mena I, De Vrieze J, Aslam S, Stadlbauer D, Meekins DA, McDowell CD, Balaraman V, Richt JA, De Geest BG, Miorin L; PVI study group; Krammer F, Simon V, García-Sastre A, Schotsaert M. Rathnasinghe R, et al. Among authors: kehrer t. medRxiv [Preprint]. 2021 Jan 20:2021.01.19.21249592. doi: 10.1101/2021.01.19.21249592. medRxiv. 2021. PMID: 33501468 Free PMC article. Preprint.
Unambiguous detection of SARS-CoV-2 subgenomic mRNAs with single cell RNA sequencing.
Cohen P, DeGrace EJ, Danziger O, Patel RS, Barrall EA, Bobrowski T, Kehrer T, Cupic A, Miorin L, García-Sastre A, Rosenberg BR. Cohen P, et al. Among authors: kehrer t. bioRxiv [Preprint]. 2023 Feb 23:2021.11.22.469642. doi: 10.1101/2021.11.22.469642. bioRxiv. 2023. Update in: Microbiol Spectr. 2023 Sep 7:e0077623. doi: 10.1128/spectrum.00776-23 PMID: 34845443 Free PMC article. Updated. Preprint.
Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression.
Zhang K, Miorin L, Makio T, Dehghan I, Gao S, Xie Y, Zhong H, Esparza M, Kehrer T, Kumar A, Hobman TC, Ptak C, Gao B, Minna JD, Chen Z, García-Sastre A, Ren Y, Wozniak RW, Fontoura BMA. Zhang K, et al. Among authors: kehrer t. Sci Adv. 2021 Feb 5;7(6):eabe7386. doi: 10.1126/sciadv.abe7386. Print 2021 Feb. Sci Adv. 2021. PMID: 33547084 Free PMC article.
Prophylactic protection against respiratory viruses conferred by a prototype live attenuated influenza virus vaccine.
Rathnasinghe R, Salvatore M, Zheng H, Jangra S, Kehrer T, Mena I, Schotsaert M, Muster T, Palese P, García-Sastre A. Rathnasinghe R, et al. Among authors: kehrer t. bioRxiv [Preprint]. 2021 Apr 28:2021.04.28.441797. doi: 10.1101/2021.04.28.441797. bioRxiv. 2021. Update in: Sci Rep. 2021 Nov 12;11(1):22164. doi: 10.1038/s41598-021-01780-8 PMID: 33948589 Free PMC article. Updated. Preprint.
Hepatitis C virus drugs that inhibit SARS-CoV-2 papain-like protease synergize with remdesivir to suppress viral replication in cell culture.
Bafna K, White K, Harish B, Rosales R, Ramelot TA, Acton TB, Moreno E, Kehrer T, Miorin L, Royer CA, García-Sastre A, Krug RM, Montelione GT. Bafna K, et al. Among authors: kehrer t. Cell Rep. 2021 May 18;35(7):109133. doi: 10.1016/j.celrep.2021.109133. Epub 2021 Apr 27. Cell Rep. 2021. PMID: 33984267 Free PMC article.
Functional Effects of Cardiomyocyte Injury in COVID-19.
Siddiq MM, Chan AT, Miorin L, Yadaw AS, Beaumont KG, Kehrer T, Cupic A, White KM, Tolentino RE, Hu B, Stern AD, Tavassoly I, Hansen J, Sebra R, Martinez P, Prabha S, Dubois N, Schaniel C, Iyengar-Kapuganti R, Kukar N, Giustino G, Sud K, Nirenberg S, Kovatch P, Albrecht RA, Goldfarb J, Croft L, McLaughlin MA, Argulian E, Lerakis S, Narula J, García-Sastre A, Iyengar R. Siddiq MM, et al. Among authors: kehrer t. J Virol. 2022 Jan 26;96(2):e0106321. doi: 10.1128/JVI.01063-21. Epub 2021 Oct 20. J Virol. 2022. PMID: 34669512 Free PMC article.
35 results