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204 results

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Page 1
GABA Increases Sensory Transmission In Monkeys.
Mahrous AA, Liang L, Balaguer JM, Ho JC, Hari K, Grigsby EM, Karapetyan V, Damiani A, Fields DP, Gonzalez-Martinez JA, Gerszten PC, Bennett DJ, Heckman CJ, Pirondini E, Capogrosso M. Mahrous AA, et al. Among authors: bennett dj. bioRxiv [Preprint]. 2023 Dec 28:2023.12.28.573467. doi: 10.1101/2023.12.28.573467. bioRxiv. 2023. PMID: 38234767 Free PMC article. Preprint.
Pharmacological blocking of spinal GABAA receptors in monkeys reduces sensory transmission to the spinal cord, thalamus, and cortex.
Mahrous AA, Liang L, Balaguer JM, Ho JC, Grigsby EM, Karapetyan V, Damiani A, Fields DP, Gonzalez-Martinez JA, Gerszten PC, Bennett DJ, Heckman CJ, Pirondini E, Capogrosso M. Mahrous AA, et al. Among authors: bennett dj. Cell Rep. 2024 Dec 18;44(1):115100. doi: 10.1016/j.celrep.2024.115100. Online ahead of print. Cell Rep. 2024. PMID: 39700009 Free article.
Discovery of MK-1084: An Orally Bioavailable and Low-Dose KRASG12C Inhibitor.
Ma X, Sloman DL, Duggal R, Anderson KD, Ballard JE, Bharathan I, Brynczka C, Gathiaka S, Henderson TJ, Lyons TW, Miller R, Munsell EV, Orth P, Otte RD, Palani A, Rankic DA, Robinson MR, Sather AC, Solban N, Song XS, Wen X, Xu Z, Yang Y, Yang R, Day PJ, Stoeck A, Bennett DJ, Han Y. Ma X, et al. Among authors: bennett dj. J Med Chem. 2024 Jul 11;67(13):11024-11052. doi: 10.1021/acs.jmedchem.4c00572. Epub 2024 Jun 26. J Med Chem. 2024. PMID: 38924388 Clinical Trial.
Targeting complement C3a receptor resolves mitochondrial hyperfusion and subretinal microglial activation in progranulin-deficient frontotemporal dementia.
Tan LX, Oertel FC, Cheng A, Cobigo Y, Keihani A, Bennett DJ, Abdelhak A, Montes SC, Chapman M, Chen RY, Cordano C, Ward ME, Casaletto K, Kramer JH, Rosen HJ, Boxer A, Miller BL, Green AJ, Elahi FM, Lakkaraju A. Tan LX, et al. Among authors: bennett dj. bioRxiv [Preprint]. 2024 Jun 1:2024.05.29.595206. doi: 10.1101/2024.05.29.595206. bioRxiv. 2024. PMID: 38854134 Free PMC article. Preprint.
Synaptic injury in the inner plexiform layer of the retina is associated with progression in multiple sclerosis.
Cordano C, Werneburg S, Abdelhak A, Bennett DJ, Beaudry-Richard A, Duncan GJ, Oertel FC, Boscardin WJ, Yiu HH, Jabassini N, Merritt L, Nocera S, Sin JH, Samana IP, Condor Montes SY, Ananth K, Bischof A; UCSF MS EPIC Team; Nourbakhsh B, Hauser SL, Cree BAC, Emery B, Schafer DP, Chan JR, Green AJ. Cordano C, et al. Among authors: bennett dj. Cell Rep Med. 2024 Apr 16;5(4):101490. doi: 10.1016/j.xcrm.2024.101490. Epub 2024 Apr 3. Cell Rep Med. 2024. PMID: 38574736 Free PMC article.
Intrinsic motoneuron properties in typical human development.
Mohammadalinejad G, Afsharipour B, Yacyshyn A, Duchcherer J, Bashuk J, Bennett E, Pearcey GEP, Negro F, Quinlan KA, Bennett DJ, Gorassini MA. Mohammadalinejad G, et al. Among authors: bennett dj. J Physiol. 2024 May;602(9):2061-2087. doi: 10.1113/JP285756. Epub 2024 Mar 30. J Physiol. 2024. PMID: 38554126 Free PMC article.
Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease.
Kattar SD, Gulati A, Margrey KA, Keylor MH, Ardolino M, Yan X, Johnson R, Palte RL, McMinn SE, Nogle L, Su J, Xiao D, Piesvaux J, Lee S, Hegde LG, Woodhouse JD, Faltus R, Moy LY, Xiong T, Ciaccio PJ, Pearson K, Patel M, Otte KM, Leyns CEG, Kennedy ME, Bennett DJ, DiMauro EF, Fell MJ, Fuller PH. Kattar SD, et al. Among authors: bennett dj. J Med Chem. 2023 Nov 9;66(21):14912-14927. doi: 10.1021/acs.jmedchem.3c01486. Epub 2023 Oct 20. J Med Chem. 2023. PMID: 37861679
204 results