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Accelerating therapeutics development during a pandemic: population pharmacokinetics of the long-acting antibody combination AZD7442 (tixagevimab/cilgavimab) in the prophylaxis and treatment of COVID-19.
Clegg LE, Stepanov O, Schmidt H, Tang W, Zhang H, Webber C, Cohen TS, Esser MT, Någård M. Clegg LE, et al. Antimicrob Agents Chemother. 2024 May 2;68(5):e0158723. doi: 10.1128/aac.01587-23. Epub 2024 Mar 27. Antimicrob Agents Chemother. 2024. PMID: 38534112 Free PMC article.
Systems Pharmacology of VEGF165b in Peripheral Artery Disease.
Clegg LE, Ganta VC, Annex BH, Mac Gabhann F. Clegg LE, et al. CPT Pharmacometrics Syst Pharmacol. 2017 Dec;6(12):833-844. doi: 10.1002/psp4.12261. Epub 2017 Nov 28. CPT Pharmacometrics Syst Pharmacol. 2017. PMID: 29193887 Free PMC article.
Reduction of Cardiovascular Risk and Improved Estimated Glomerular Filtration Rate by SGLT2 Inhibitors, Including Dapagliflozin, Is Consistent Across the Class: An Analysis of the Placebo Arm of EXSCEL.
Clegg LE, Heerspink HJL, Penland RC, Tang W, Boulton DW, Bachina S, Fox RD, Fenici P, Thuresson M, Mentz RJ, Hernandez AF, Holman RR. Clegg LE, et al. Diabetes Care. 2019 Feb;42(2):318-326. doi: 10.2337/dc18-1871. Epub 2018 Dec 6. Diabetes Care. 2019. PMID: 30523029 Clinical Trial.
AZD3152 neutralizes SARS-CoV-2 historical and contemporary variants and is protective in hamsters and well tolerated in adults.
Cai Y, Diallo S, Rosenthal K, Ren K, Flores DJ, Dippel A, Oganesyan V, van Dyk N, Chen X, Cantu E, Choudhary R, Sulikowski M, Adissu H, Chawla B, Kar S, Liu C, Dijokaite-Guraliuc A, Mongkolsapaya J, Rajan S, Loo YM, Beavon R, Webber C, Chang LJ, Thomas S, Clegg L, Zhang H, Screaton GR, Philbin N, Harre M, Selim A, Martinez-Alier N, Uriel A, Cohen TS, Perez JL, Esser MT, Blair W, Francica JR. Cai Y, et al. Sci Transl Med. 2024 Jun 26;16(753):eado2817. doi: 10.1126/scitranslmed.ado2817. Epub 2024 Jun 26. Sci Transl Med. 2024. PMID: 38924429
18 results