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Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation.
Chen YF, Ghazala M, Friedrich RM, Cordova BA, Petroze FN, Srinivasan R, Allan KC, Yan DF, Sax JL, Carr K, Tomchuck SL, Fedorov Y, Huang AY, Desai AB, Adams DJ. Chen YF, et al. Among authors: huang ay. Nat Chem Biol. 2024 Oct;20(10):1260-1271. doi: 10.1038/s41589-024-01586-5. Epub 2024 Mar 25. Nat Chem Biol. 2024. PMID: 38528120
Oral TGF-βR1 inhibitor Vactosertib promotes osteosarcoma regression by targeting tumor proliferation and enhancing anti-tumor immunity.
Choi SH, Myers J, Tomchuck S, Bonner M, Eid S, Kingsley D, VanHeyst K, Kim SJ, Kim BG, Huang AY. Choi SH, et al. Among authors: huang ay. Res Sq [Preprint]. 2023 Apr 3:rs.3.rs-2709282. doi: 10.21203/rs.3.rs-2709282/v1. Res Sq. 2023. Update in: Cancer Commun (Lond). 2024 Aug;44(8):884-888. doi: 10.1002/cac2.12589 PMID: 37066414 Free PMC article. Updated. Preprint.
Piezo1 facilitates optimal T cell activation during tumor challenge.
Abiff M, Alshebremi M, Bonner M, Myers JT, Kim BG, Tomchuck SL, Santin A, Kingsley D, Choi SH, Huang AY. Abiff M, et al. Among authors: huang ay. Oncoimmunology. 2023 Nov 22;12(1):2281179. doi: 10.1080/2162402X.2023.2281179. eCollection 2023. Oncoimmunology. 2023. PMID: 38126029 Free PMC article.
Oral transforming growth factor-beta receptor 1 inhibitor vactosertib promotes osteosarcoma regression by targeting tumor proliferation and enhancing anti-tumor immunity.
Choi SH, Myers JT, Tomchuck SL, Bonner M, Eid S, Kingsley DT, VanHeyst KA, Kim SJ, Kim BG, Huang AY. Choi SH, et al. Among authors: huang ay. Cancer Commun (Lond). 2024 Aug;44(8):884-888. doi: 10.1002/cac2.12589. Epub 2024 Jul 6. Cancer Commun (Lond). 2024. PMID: 38970391 Free PMC article. No abstract available.
Positively selected enhancer elements endow osteosarcoma cells with metastatic competence.
Morrow JJ, Bayles I, Funnell APW, Miller TE, Saiakhova A, Lizardo MM, Bartels CF, Kapteijn MY, Hung S, Mendoza A, Dhillon G, Chee DR, Myers JT, Allen F, Gambarotti M, Righi A, DiFeo A, Rubin BP, Huang AY, Meltzer PS, Helman LJ, Picci P, Versteeg HH, Stamatoyannopoulos JA, Khanna C, Scacheri PC. Morrow JJ, et al. Among authors: huang ay. Nat Med. 2018 Feb;24(2):176-185. doi: 10.1038/nm.4475. Epub 2018 Jan 15. Nat Med. 2018. PMID: 29334376 Free PMC article.
Cx25 contributes to leukemia cell communication and chemosensitivity.
Sinyuk M, Alvarado AG, Nesmiyanov P, Shaw J, Mulkearns-Hubert EE, Eurich JT, Hale JS, Bogdanova A, Hitomi M, Maciejewski J, Huang AY, Saunthararajah Y, Lathia JD. Sinyuk M, et al. Among authors: huang ay. Oncotarget. 2015 Oct 13;6(31):31508-21. doi: 10.18632/oncotarget.5226. Oncotarget. 2015. PMID: 26375552 Free PMC article.
251 results