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Page 1
Protective antibodies target cryptic epitope unmasked by cleavage of malaria sporozoite protein.
Dacon C, Moskovitz R, Swearingen K, Da Silva Pereira L, Flores-Garcia Y, Aleshnick M, Kanatani S, Flynn B, Molina-Cruz A, Wollenberg K, Traver M, Kirtley P, Purser L, Dillon M, Bonilla B, Franco A, Petros S, Kritzberg J, Tucker C, Paez GG, Gupta P, Shears MJ, Pazzi J, Edgar JM, Teng AA, Belmonte A, Oda K, Doumbo S, Krymskaya L, Skinner J, Li S, Ghosal S, Kayentao K, Ongoiba A, Vaughan A, Campo JJ, Traore B, Barillas-Mury C, Wijayalath W, Idris A, Crompton PD, Sinnis P, Wilder BK, Zavala F, Seder RA, Wilson IA, Tan J. Dacon C, et al. Among authors: sinnis p. Science. 2025 Jan 3;387(6729):eadr0510. doi: 10.1126/science.adr0510. Epub 2025 Jan 3. Science. 2025. PMID: 39745947
The Plasmodium circumsporozoite protein.
Singer M, Kanatani S, Castillo SG, Frischknecht F, Sinnis P. Singer M, et al. Among authors: sinnis p. Trends Parasitol. 2024 Dec;40(12):1124-1134. doi: 10.1016/j.pt.2024.10.017. Epub 2024 Nov 20. Trends Parasitol. 2024. PMID: 39572325 Review.
Identification of the drug/metabolite transporter 1 as a marker of quinine resistance in a NF54×Cam3.II P. falciparum genetic cross.
Kanai M, Mok S, Yeo T, Shears MJ, Ross LS, Jeon JH, Narwal S, Haile MT, Tripathi AK, Mlambo G, Kim J, Gil-Iturbe E, Okombo J, Fairhurst KJ, Bloxham T, Bridgford JL, Sheth T, Ward KE, Park H, Rozenberg FD, Quick M, Mancia F, Lee MCS, Small-Saunders JL, Uhlemann AC, Sinnis P, Fidock DA. Kanai M, et al. Among authors: sinnis p. bioRxiv [Preprint]. 2024 Oct 1:2024.09.27.615529. doi: 10.1101/2024.09.27.615529. bioRxiv. 2024. PMID: 39386571 Free PMC article. Preprint.
The major surface protein of malaria sporozoites is GPI-anchored to the plasma membrane.
Nagar R, Garcia Castillo SS, Pinzon-Ortiz M, Patray S, Coppi A, Kanatani S, Moritz RL, Swearingen KE, Ferguson MAJ, Sinnis P. Nagar R, et al. Among authors: sinnis p. bioRxiv [Preprint]. 2024 May 21:2024.05.21.595204. doi: 10.1101/2024.05.21.595204. bioRxiv. 2024. Update in: J Biol Chem. 2024 Aug;300(8):107557. doi: 10.1016/j.jbc.2024.107557 PMID: 38826328 Free PMC article. Updated. Preprint.
Quantification of sporozoite expelling by Anopheles mosquitoes infected with laboratory and naturally circulating P. falciparum gametocytes.
Andolina C, Graumans W, Guelbeogo M, van Gemert GJ, Ramijth J, Harouna S, Soumanaba Z, Stoter R, Vegte-Bolmer M, Pangos M, Sinnis P, Collins K, Staedke SG, Tiono AB, Drakeley C, Lanke K, Bousema T. Andolina C, et al. Among authors: sinnis p. Elife. 2024 Mar 22;12:RP90989. doi: 10.7554/eLife.90989. Elife. 2024. PMID: 38517746 Free PMC article.
Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness.
Mok S, Yeo T, Hong D, Shears MJ, Ross LS, Ward KE, Dhingra SK, Kanai M, Bridgford JL, Tripathi AK, Mlambo G, Burkhard AY, Ansbro MR, Fairhurst KJ, Gil-Iturbe E, Park H, Rozenberg FD, Kim J, Mancia F, Fairhurst RM, Quick M, Uhlemann AC, Sinnis P, Fidock DA. Mok S, et al. Among authors: sinnis p. Sci Adv. 2023 Nov 10;9(45):eadi2364. doi: 10.1126/sciadv.adi2364. Epub 2023 Nov 8. Sci Adv. 2023. PMID: 37939186 Free PMC article.
Clinically relevant atovaquone-resistant human malaria parasites fail to transmit by mosquito.
Balta VA, Stiffler D, Sayeed A, Tripathi AK, Elahi R, Mlambo G, Bakshi RP, Dziedzic AG, Jedlicka AE, Nenortas E, Romero-Rodriguez K, Canonizado MA, Mann A, Owen A, Sullivan DJ, Prigge ST, Sinnis P, Shapiro TA. Balta VA, et al. Among authors: sinnis p. Nat Commun. 2023 Oct 12;14(1):6415. doi: 10.1038/s41467-023-42030-x. Nat Commun. 2023. PMID: 37828012 Free PMC article.
Novel insights into the role of long non-coding RNA in the human malaria parasite, Plasmodium falciparum.
Batugedara G, Lu XM, Hristov B, Abel S, Chahine Z, Hollin T, Williams D, Wang T, Cort A, Lenz T, Thompson TA, Prudhomme J, Tripathi AK, Xu G, Cudini J, Dogga S, Lawniczak M, Noble WS, Sinnis P, Le Roch KG. Batugedara G, et al. Among authors: sinnis p. Nat Commun. 2023 Aug 22;14(1):5086. doi: 10.1038/s41467-023-40883-w. Nat Commun. 2023. PMID: 37607941 Free PMC article.
115 results