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A TBK1 variant causes autophagolysosomal and motoneuron pathology without neuroinflammation in mice.
Brenner D, Sieverding K, Srinidhi J, Zellner S, Secker C, Yilmaz R, Dyckow J, Amr S, Ponomarenko A, Tunaboylu E, Douahem Y, Schlag JS, Rodríguez Martínez L, Kislinger G, Niemann C, Nalbach K, Ruf WP, Uhl J, Hollenbeck J, Schirmer L, Catanese A, Lobsiger CS, Danzer KM, Yilmazer-Hanke D, Münch C, Koch P, Freischmidt A, Fetting M, Behrends C, Parlato R, Weishaupt JH. Brenner D, et al. Among authors: schirmer l. J Exp Med. 2024 May 6;221(5):e20221190. doi: 10.1084/jem.20221190. Epub 2024 Mar 22. J Exp Med. 2024. PMID: 38517332 Free PMC article.
Long-term dynamics of multiple sclerosis iron rim lesions.
Weber CE, Wittayer M, Kraemer M, Dabringhaus A, Bail K, Platten M, Schirmer L, Gass A, Eisele P. Weber CE, et al. Among authors: schirmer l. Mult Scler Relat Disord. 2022 Jan;57:103340. doi: 10.1016/j.msard.2021.103340. Epub 2021 Oct 18. Mult Scler Relat Disord. 2022. PMID: 35158450
Diversity and Function of Glial Cell Types in Multiple Sclerosis.
Schirmer L, Schafer DP, Bartels T, Rowitch DH, Calabresi PA. Schirmer L, et al. Trends Immunol. 2021 Mar;42(3):228-247. doi: 10.1016/j.it.2021.01.005. Epub 2021 Feb 13. Trends Immunol. 2021. PMID: 33593693 Free PMC article. Review.
Queuosine-tRNA promotes sex-dependent learning and memory formation by maintaining codon-biased translation elongation speed.
Cirzi C, Dyckow J, Legrand C, Schott J, Guo W, Perez Hernandez D, Hisaoka M, Parlato R, Pitzer C, van der Hoeven F, Dittmar G, Helm M, Stoecklin G, Schirmer L, Lyko F, Tuorto F. Cirzi C, et al. Among authors: schirmer l. EMBO J. 2023 Oct 4;42(19):e112507. doi: 10.15252/embj.2022112507. Epub 2023 Aug 23. EMBO J. 2023. PMID: 37609797 Free PMC article.
Cell type mapping of inflammatory muscle diseases highlights selective myofiber vulnerability in inclusion body myositis.
Wischnewski S, Thäwel T, Ikenaga C, Kocharyan A, Lerma-Martin C, Zulji A, Rausch HW, Brenner D, Thomas L, Kutza M, Wick B, Trobisch T, Preusse C, Haeussler M, Leipe J, Ludolph A, Rosenbohm A, Hoke A, Platten M, Weishaupt JH, Sommer CJ, Stenzel W, Lloyd TE, Schirmer L. Wischnewski S, et al. Among authors: schirmer l. Nat Aging. 2024 Jul;4(7):969-983. doi: 10.1038/s43587-024-00645-9. Epub 2024 Jun 4. Nat Aging. 2024. PMID: 38834884 Free PMC article.
Cell type-specific transcriptomics identifies neddylation as a novel therapeutic target in multiple sclerosis.
Kim K, Pröbstel AK, Baumann R, Dyckow J, Landefeld J, Kogl E, Madireddy L, Loudermilk R, Eggers EL, Singh S, Caillier SJ, Hauser SL, Cree BAC; UCSF MS-EPIC Team; Schirmer L, Wilson MR, Baranzini SE. Kim K, et al. Among authors: schirmer l. Brain. 2021 Mar 3;144(2):450-461. doi: 10.1093/brain/awaa421. Brain. 2021. PMID: 33374005 Free PMC article.
Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination.
Kapell H, Fazio L, Dyckow J, Schwarz S, Cruz-Herranz A, Mayer C, Campos J, D'Este E, Möbius W, Cordano C, Pröbstel AK, Gharagozloo M, Zulji A, Narayanan Naik V, Delank A, Cerina M, Müntefering T, Lerma-Martin C, Sonner JK, Sin JH, Disse P, Rychlik N, Sabeur K, Chavali M, Srivastava R, Heidenreich M, Fitzgerald KC, Seebohm G, Stadelmann C, Hemmer B, Platten M, Jentsch TJ, Engelhardt M, Budde T, Nave KA, Calabresi PA, Friese MA, Green AJ, Acuna C, Rowitch DH, Meuth SG, Schirmer L. Kapell H, et al. Among authors: schirmer l. J Clin Invest. 2023 Apr 3;133(7):e164223. doi: 10.1172/JCI164223. J Clin Invest. 2023. PMID: 36719741 Free PMC article.
106 results