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GNTI-122: an autologous antigen-specific engineered Treg cell therapy for type 1 diabetes.
Uenishi GI, Repic M, Yam JY, Landuyt A, Saikumar-Lakshmi P, Guo T, Zarin P, Sassone-Corsi M, Chicoine A, Kellogg H, Hunt M, Drow T, Tewari R, Cook PJ, Yang SJ, Cerosaletti K, Schweinoch D, Guiastrennec B, James E, Patel C, Chen TF, Buckner JH, Rawlings DJ, Wickham TJ, Mueller KT. Uenishi GI, et al. JCI Insight. 2024 Feb 8;9(6):e171844. doi: 10.1172/jci.insight.171844. JCI Insight. 2024. PMID: 38516892 Free PMC article.
A chemically inducible IL-2 receptor signaling complex allows for effective in vitro and in vivo selection of engineered CD4+ T cells.
Cook PJ, Yang SJ, Uenishi GI, Grimm A, West SE, Wang LJ, Jacobs C, Repele A, Drow T, Boukhris A, Dahl NP, Sommer K, Scharenberg AM, Rawlings DJ. Cook PJ, et al. Among authors: uenishi gi. Mol Ther. 2023 Aug 2;31(8):2472-2488. doi: 10.1016/j.ymthe.2023.04.021. Epub 2023 May 4. Mol Ther. 2023. PMID: 37147803 Free PMC article.
Production, safety and efficacy of iPSC-derived mesenchymal stromal cells in acute steroid-resistant graft versus host disease: a phase I, multicenter, open-label, dose-escalation study.
Bloor AJC, Patel A, Griffin JE, Gilleece MH, Radia R, Yeung DT, Drier D, Larson LS, Uenishi GI, Hei D, Kelly K, Slukvin I, Rasko JEJ. Bloor AJC, et al. Among authors: uenishi gi. Nat Med. 2020 Nov;26(11):1720-1725. doi: 10.1038/s41591-020-1050-x. Epub 2020 Sep 14. Nat Med. 2020. PMID: 32929265 Clinical Trial.