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Page 1
Reduced function of the adaptor SH2B3 promotes T1D via altered gc cytokine-regulated, T cell intrinsic immune tolerance.
Watson TK, Rosen ABI, Drow T, Medjo JA, MacQuivey MA, Ge Y, Liggitt HD, Grosvenor DA, Dill-McFarland KA, Altman MC, Concannon PJ, Buckner JH, Rawlings DJ, Allenspach EJ. Watson TK, et al. Among authors: drow t. bioRxiv [Preprint]. 2024 Aug 6:2024.08.02.606362. doi: 10.1101/2024.08.02.606362. bioRxiv. 2024. PMID: 39211124 Free PMC article. Preprint.
GNTI-122: an autologous antigen-specific engineered Treg cell therapy for type 1 diabetes.
Uenishi GI, Repic M, Yam JY, Landuyt A, Saikumar-Lakshmi P, Guo T, Zarin P, Sassone-Corsi M, Chicoine A, Kellogg H, Hunt M, Drow T, Tewari R, Cook PJ, Yang SJ, Cerosaletti K, Schweinoch D, Guiastrennec B, James E, Patel C, Chen TF, Buckner JH, Rawlings DJ, Wickham TJ, Mueller KT. Uenishi GI, et al. Among authors: drow t. JCI Insight. 2024 Feb 8;9(6):e171844. doi: 10.1172/jci.insight.171844. JCI Insight. 2024. PMID: 38516892 Free PMC article.
A chemically inducible IL-2 receptor signaling complex allows for effective in vitro and in vivo selection of engineered CD4+ T cells.
Cook PJ, Yang SJ, Uenishi GI, Grimm A, West SE, Wang LJ, Jacobs C, Repele A, Drow T, Boukhris A, Dahl NP, Sommer K, Scharenberg AM, Rawlings DJ. Cook PJ, et al. Among authors: drow t. Mol Ther. 2023 Aug 2;31(8):2472-2488. doi: 10.1016/j.ymthe.2023.04.021. Epub 2023 May 4. Mol Ther. 2023. PMID: 37147803 Free PMC article.
Corrigendum to "Islet allografts expressing a PD-L1 and IDO fusion protein evade immune rejection and reverse preexisting diabetes in immunocompetent mice without systemic immunosuppression" [American Journal of Transplantation (2022) 2571-2585].
Paul PK, Das R, Drow T, Nylen EA, Henrique de Souza A, Wang Z, Wood MW, Davis DB, Bjorling DE, Galipeau J. Paul PK, et al. Among authors: drow t. Am J Transplant. 2023 May;23(5):693. doi: 10.1016/j.ajt.2023.02.019. Epub 2023 Mar 6. Am J Transplant. 2023. PMID: 36907701 Free PMC article. No abstract available.
Pancreatic islet-specific engineered Tregs exhibit robust antigen-specific and bystander immune suppression in type 1 diabetes models.
Yang SJ, Singh AK, Drow T, Tappen T, Honaker Y, Barahmand-Pour-Whitman F, Linsley PS, Cerosaletti K, Mauk K, Xiang Y, Smith J, Mortensen E, Cook PJ, Sommer K, Khan I, Liggitt D, Rawlings DJ, Buckner JH. Yang SJ, et al. Among authors: drow t. Sci Transl Med. 2022 Oct 5;14(665):eabn1716. doi: 10.1126/scitranslmed.abn1716. Epub 2022 Oct 5. Sci Transl Med. 2022. PMID: 36197963