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GNTI-122: an autologous antigen-specific engineered Treg cell therapy for type 1 diabetes.
Uenishi GI, Repic M, Yam JY, Landuyt A, Saikumar-Lakshmi P, Guo T, Zarin P, Sassone-Corsi M, Chicoine A, Kellogg H, Hunt M, Drow T, Tewari R, Cook PJ, Yang SJ, Cerosaletti K, Schweinoch D, Guiastrennec B, James E, Patel C, Chen TF, Buckner JH, Rawlings DJ, Wickham TJ, Mueller KT. Uenishi GI, et al. Among authors: cerosaletti k. JCI Insight. 2024 Feb 8;9(6):e171844. doi: 10.1172/jci.insight.171844. JCI Insight. 2024. PMID: 38516892 Free PMC article.
The Type 1 Diabetes T Cell Receptor and B Cell Receptor Repository in the AIRR Data Commons: a practical guide for access, use and contributions through the Type 1 Diabetes AIRR Consortium.
Hanna SJ, Bonami RH, Corrie B, Westley M, Posgai AL, Luning Prak ET, Breden F, Michels AW, Brusko TM; Type 1 Diabetes AIRR Consortium. Hanna SJ, et al. Diabetologia. 2025 Jan;68(1):186-202. doi: 10.1007/s00125-024-06298-y. Epub 2024 Oct 29. Diabetologia. 2025. PMID: 39467874 Free PMC article.
Self-reactive germline-like TCR alpha chains shared between blood and pancreas.
Linsley P, Nakayama M, Balmas E, Chen J, Pour F, Bansal S, Serti E, Speake C, Pugliese A, Cerosaletti K. Linsley P, et al. Among authors: cerosaletti k. Res Sq [Preprint]. 2023 Oct 20:rs.3.rs-3446917. doi: 10.21203/rs.3.rs-3446917/v1. Res Sq. 2023. Update in: Nat Commun. 2024 Jun 13;15(1):4971. doi: 10.1038/s41467-024-48833-w PMID: 37886513 Free PMC article. Updated. Preprint.
A first-in-human, open-label Phase 1b and a randomised, double-blind Phase 2a clinical trial in recent-onset type 1 diabetes with AG019 as monotherapy and in combination with teplizumab.
Mathieu C, Wiedeman A, Cerosaletti K, Long SA, Serti E, Cooney L, Vermeiren J, Caluwaerts S, Van Huynegem K, Steidler L, Blomme S, Rottiers P, Nepom GT, Herold KC; AG019-T1D-101 Trial Investigators. Mathieu C, et al. Among authors: cerosaletti k. Diabetologia. 2024 Jan;67(1):27-41. doi: 10.1007/s00125-023-06014-2. Epub 2023 Oct 2. Diabetologia. 2024. PMID: 37782353 Free PMC article. Clinical Trial.
74 results