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Page 1
ACLY and ACSS2 link nutrient-dependent chromatin accessibility to CD8 T cell effector responses.
Kaymak I, Watson MJ, Oswald BM, Ma S, Johnson BK, DeCamp LM, Mabvakure BM, Luda KM, Ma EH, Lau K, Fu Z, Muhire B, Kitchen-Goosen SM, Vander Ark A, Dahabieh MS, Samborska B, Vos M, Shen H, Fan ZP, Roddy TP, Kingsbury GA, Sousa CM, Krawczyk CM, Williams KS, Sheldon RD, Kaech SM, Roy DG, Jones RG. Kaymak I, et al. Among authors: kitchen goosen sm. J Exp Med. 2024 Sep 2;221(9):e20231820. doi: 10.1084/jem.20231820. Epub 2024 Aug 16. J Exp Med. 2024. PMID: 39150482
NRF2-dependent regulation of the prostacyclin receptor PTGIR drives CD8 T cell exhaustion.
Dahabieh MS, DeCamp LM, Oswald BM, Kitchen-Goosen SM, Fu Z, Vos M, Compton SE, Longo J, Williams KS, Ellis AE, Johnson A, Sodiya I, Vincent M, Lee H, Sheldon RD, Krawczyk CM, Yao C, Wu T, Jones RG. Dahabieh MS, et al. Among authors: kitchen goosen sm. bioRxiv [Preprint]. 2024 Jun 28:2024.06.23.600279. doi: 10.1101/2024.06.23.600279. bioRxiv. 2024. PMID: 38979360 Free PMC article. Preprint.
13C metabolite tracing reveals glutamine and acetate as critical in vivo fuels for CD8 T cells.
Ma EH, Dahabieh MS, DeCamp LM, Kaymak I, Kitchen-Goosen SM, Oswald BM, Longo J, Roy DG, Verway MJ, Johnson RM, Samborska B, Duimstra LR, Scullion CA, Steadman M, Vos M, Roddy TP, Krawczyk CM, Williams KS, Sheldon RD, Jones RG. Ma EH, et al. Among authors: kitchen goosen sm. Sci Adv. 2024 May 31;10(22):eadj1431. doi: 10.1126/sciadv.adj1431. Epub 2024 May 29. Sci Adv. 2024. PMID: 38809979 Free PMC article.
Cell Context Is the Third Axis of Synergy for the Combination of ATR Inhibition and Cisplatin in Ewing Sarcoma.
Jess J, Sorensen KM, Boguslawski EA, Stout MC, Madaj ZB, Caiello BP, Pomaville M, Wilson ER, Kinn-Gurzo SS, Parker CC, Veluvolu SM, Brysgel TV, Kaufman R, Kitchen-Goosen SM, Gedminas JM, Grohar PJ. Jess J, et al. Among authors: kitchen goosen sm. Clin Cancer Res. 2024 Aug 15;30(16):3533-3548. doi: 10.1158/1078-0432.CCR-23-3063. Clin Cancer Res. 2024. PMID: 38506712
Ketolysis drives CD8+ T cell effector function through effects on histone acetylation.
Luda KM, Longo J, Kitchen-Goosen SM, Duimstra LR, Ma EH, Watson MJ, Oswald BM, Fu Z, Madaj Z, Kupai A, Dickson BM, DeCamp LM, Dahabieh MS, Compton SE, Teis R, Kaymak I, Lau KH, Kelly DP, Puchalska P, Williams KS, Krawczyk CM, Lévesque D, Boisvert FM, Sheldon RD, Rothbart SB, Crawford PA, Jones RG. Luda KM, et al. Among authors: kitchen goosen sm. Immunity. 2023 Sep 12;56(9):2021-2035.e8. doi: 10.1016/j.immuni.2023.07.002. Epub 2023 Jul 28. Immunity. 2023. PMID: 37516105 Free PMC article.
13C metabolite tracing reveals glutamine and acetate as critical in vivo fuels for CD8+ T cells.
Ma EH, Dahabieh MS, DeCamp LM, Kaymak I, Kitchen-Goosen SM, Roy DG, Verway MJ, Johnson RM, Samborska B, Scullion CA, Steadman M, Vos M, Roddy TP, Krawczyk CM, Williams KS, Sheldon RD, Jones RG. Ma EH, et al. Among authors: kitchen goosen sm. bioRxiv [Preprint]. 2023 Jun 11:2023.06.09.544407. doi: 10.1101/2023.06.09.544407. bioRxiv. 2023. Update in: Sci Adv. 2024 May 31;10(22):eadj1431. doi: 10.1126/sciadv.adj1431 PMID: 37333111 Free PMC article. Updated. Preprint.
LKB1 controls inflammatory potential through CRTC2-dependent histone acetylation.
Compton SE, Kitchen-Goosen SM, DeCamp LM, Lau KH, Mabvakure B, Vos M, Williams KS, Wong KK, Shi X, Rothbart SB, Krawczyk CM, Jones RG. Compton SE, et al. Among authors: kitchen goosen sm. Mol Cell. 2023 Jun 1;83(11):1872-1886.e5. doi: 10.1016/j.molcel.2023.04.017. Epub 2023 May 11. Mol Cell. 2023. PMID: 37172591 Free article.
Carbon source availability drives nutrient utilization in CD8+ T cells.
Kaymak I, Luda KM, Duimstra LR, Ma EH, Longo J, Dahabieh MS, Faubert B, Oswald BM, Watson MJ, Kitchen-Goosen SM, DeCamp LM, Compton SE, Fu Z, DeBerardinis RJ, Williams KS, Sheldon RD, Jones RG. Kaymak I, et al. Among authors: kitchen goosen sm. Cell Metab. 2022 Sep 6;34(9):1298-1311.e6. doi: 10.1016/j.cmet.2022.07.012. Epub 2022 Aug 17. Cell Metab. 2022. PMID: 35981545 Free PMC article.
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