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Discovery of Novel Pyrazolylpyridine Derivatives for 20-Hydroxyeicosatetraenoic Acid Synthase Inhibitors with Selective CYP4A11/4F2 Inhibition.
Kawamura M, Kobashi Y, Tanaka H, Bohno-Mikami A, Hamada M, Ito Y, Hirata T, Ohara H, Kojima N, Koretsune H, Gunji E, Fukunaga T, Inatani S, Hasegawa Y, Suzuki A, Takahashi T, Kakinuma H. Kawamura M, et al. Among authors: kojima n. J Med Chem. 2022 Nov 10;65(21):14599-14613. doi: 10.1021/acs.jmedchem.2c01089. Epub 2022 Nov 1. J Med Chem. 2022. PMID: 36318660
Discovery of TP0628103: A Highly Potent and Selective MMP-7 Inhibitor with Reduced OATP-Mediated Clearance Designed by Shifting Isoelectric Points.
Oka Y, Abe-Sato K, Tabuse H, Yasukawa Y, Yahara T, Nishimoto T, Kamitani M, Fukunaga T, Ochiai N, Kumasaka-Abe T, Hitaka K, Gunji E, Ohara H, Takeda T, Kojima N, Asami T. Oka Y, et al. Among authors: kojima n. J Med Chem. 2024 Jan 25;67(2):1406-1420. doi: 10.1021/acs.jmedchem.3c01967. Epub 2024 Jan 12. J Med Chem. 2024. PMID: 38214909
Introduction of a carboxylic acid group into pyrazolylpyridine derivatives increased selectivity for inhibition of the 20-HETE synthase CYP4A11/4F2.
Kawamura M, Kobashi Y, Tanaka H, Bohno-Mikami A, Hamada M, Ito Y, Suzuki K, Funayama K, Hirata T, Ohara H, Koretsune H, Kojima N, Fukunaga T, Hirate M, Inatani S, Hasegawa Y, Takahashi T, Kakinuma H. Kawamura M, et al. Among authors: kojima n. Bioorg Med Chem. 2023 Oct 18;95:117505. doi: 10.1016/j.bmc.2023.117505. Online ahead of print. Bioorg Med Chem. 2023. PMID: 39491277
Discovery of TP0597850: A Selective, Chemically Stable, and Slow Tight-Binding Matrix Metalloproteinase-2 Inhibitor with a Phenylbenzamide-Pentapeptide Hybrid Scaffold.
Takeuchi T, Nomura Y, Tamita T, Nishikawa R, Kakinuma H, Kojima N, Hitaka K, Tamura Y, Kamitani M, Mima M, Nozoe A, Hayashi M. Takeuchi T, et al. Among authors: kojima n. J Med Chem. 2023 Jan 12;66(1):822-836. doi: 10.1021/acs.jmedchem.2c01698. Epub 2023 Jan 3. J Med Chem. 2023. PMID: 36595440
893 results